All-trans retinoic acid enhances the cytotoxic effect of decitabine on myelodysplastic syndromes and acute myeloid leukaemia by activating the RARα-Nrf2 complex

BACKGROUND: Decitabine (DAC) is used as the first-line therapy in patients with higher-risk myelodysplastic syndromes (HR-MDS) and elderly acute myeloid leukaemia (AML) patients unsuitable for intensive chemotherapy. However, the clinical outcomes of patients treated with DAC as a monotherapy are fa...

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Detalles Bibliográficos
Autores principales: Wang, Lu, Zhang, Qi, Ye, Li, Ye, Xingnong, Yang, Wenli, Zhang, Hua, Zhou, Xinping, Ren, Yanling, Ma, Liya, Zhang, Xiang, Mei, Chen, Xu, Gaixiang, Li, Kongfei, Luo, Yingwan, Jiang, Lingxu, Lin, Peipei, Zhu, Shuanghong, Lang, Wei, Wang, Yuxia, Shen, Chuying, Han, Yueyuan, Liu, Xiaozhen, Yang, Haiyang, Lu, Chenxi, Sun, Jie, Jin, Jie, Tong, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938271/
https://www.ncbi.nlm.nih.gov/pubmed/36482192
http://dx.doi.org/10.1038/s41416-022-02074-0

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