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Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias

Stage II cholinergic retinal waves are one of the first instances of neural activity in the visual system as they are present at a developmental timepoint in which light-evoked activity remains largely undetectable. These waves of spontaneous neural activity sweeping across the developing retina are...

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Autores principales: Tarchick, Matthew J., Clute, Dustin A., Renna, Jordan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938278/
https://www.ncbi.nlm.nih.gov/pubmed/36808155
http://dx.doi.org/10.1038/s41598-023-29572-2
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author Tarchick, Matthew J.
Clute, Dustin A.
Renna, Jordan M.
author_facet Tarchick, Matthew J.
Clute, Dustin A.
Renna, Jordan M.
author_sort Tarchick, Matthew J.
collection PubMed
description Stage II cholinergic retinal waves are one of the first instances of neural activity in the visual system as they are present at a developmental timepoint in which light-evoked activity remains largely undetectable. These waves of spontaneous neural activity sweeping across the developing retina are generated by starburst amacrine cells, depolarize retinal ganglion cells, and drive the refinement of retinofugal projections to numerous visual centers in the brain. Building from several well-established models, we assemble a spatial computational model of starburst amacrine cell-mediated wave generation and wave propagation that includes three significant advancements. First, we model the intrinsic spontaneous bursting of the starburst amacrine cells, including the slow afterhyperpolarization, which shapes the stochastic process of wave generation. Second, we establish a mechanism of wave propagation using reciprocal acetylcholine release, synchronizing the bursting activity of neighboring starburst amacrine cells. Third, we model the additional starburst amacrine cell release of GABA, changing the spatial propagation of retinal waves and in certain instances, the directional bias of the retinal wave front. In total, these advancements comprise a now more comprehensive model of wave generation, propagation, and direction bias.
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spelling pubmed-99382782023-02-19 Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias Tarchick, Matthew J. Clute, Dustin A. Renna, Jordan M. Sci Rep Article Stage II cholinergic retinal waves are one of the first instances of neural activity in the visual system as they are present at a developmental timepoint in which light-evoked activity remains largely undetectable. These waves of spontaneous neural activity sweeping across the developing retina are generated by starburst amacrine cells, depolarize retinal ganglion cells, and drive the refinement of retinofugal projections to numerous visual centers in the brain. Building from several well-established models, we assemble a spatial computational model of starburst amacrine cell-mediated wave generation and wave propagation that includes three significant advancements. First, we model the intrinsic spontaneous bursting of the starburst amacrine cells, including the slow afterhyperpolarization, which shapes the stochastic process of wave generation. Second, we establish a mechanism of wave propagation using reciprocal acetylcholine release, synchronizing the bursting activity of neighboring starburst amacrine cells. Third, we model the additional starburst amacrine cell release of GABA, changing the spatial propagation of retinal waves and in certain instances, the directional bias of the retinal wave front. In total, these advancements comprise a now more comprehensive model of wave generation, propagation, and direction bias. Nature Publishing Group UK 2023-02-17 /pmc/articles/PMC9938278/ /pubmed/36808155 http://dx.doi.org/10.1038/s41598-023-29572-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Tarchick, Matthew J.
Clute, Dustin A.
Renna, Jordan M.
Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias
title Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias
title_full Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias
title_fullStr Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias
title_full_unstemmed Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias
title_short Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias
title_sort modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938278/
https://www.ncbi.nlm.nih.gov/pubmed/36808155
http://dx.doi.org/10.1038/s41598-023-29572-2
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