Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis

ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis...

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Detalles Bibliográficos
Autores principales: Zhang, Shilan, Kapoor, Sabeeta, Tripathi, Chakrapani, Perez, Jorge Tovar, Mohan, Nivedhitha, Dashwood, Wan Mohaiza, Zhang, Ke, Rajendran, Praveen, Dashwood, Roderick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938505/
https://www.ncbi.nlm.nih.gov/pubmed/36801948
http://dx.doi.org/10.1038/s41698-023-00361-4
Descripción
Sumario:ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.

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