Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis

ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis...

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Autores principales: Zhang, Shilan, Kapoor, Sabeeta, Tripathi, Chakrapani, Perez, Jorge Tovar, Mohan, Nivedhitha, Dashwood, Wan Mohaiza, Zhang, Ke, Rajendran, Praveen, Dashwood, Roderick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938505/
https://www.ncbi.nlm.nih.gov/pubmed/36801948
http://dx.doi.org/10.1038/s41698-023-00361-4
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author Zhang, Shilan
Kapoor, Sabeeta
Tripathi, Chakrapani
Perez, Jorge Tovar
Mohan, Nivedhitha
Dashwood, Wan Mohaiza
Zhang, Ke
Rajendran, Praveen
Dashwood, Roderick
author_facet Zhang, Shilan
Kapoor, Sabeeta
Tripathi, Chakrapani
Perez, Jorge Tovar
Mohan, Nivedhitha
Dashwood, Wan Mohaiza
Zhang, Ke
Rajendran, Praveen
Dashwood, Roderick
author_sort Zhang, Shilan
collection PubMed
description ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.
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spelling pubmed-99385052023-02-20 Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis Zhang, Shilan Kapoor, Sabeeta Tripathi, Chakrapani Perez, Jorge Tovar Mohan, Nivedhitha Dashwood, Wan Mohaiza Zhang, Ke Rajendran, Praveen Dashwood, Roderick NPJ Precis Oncol Brief Communication ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection. Nature Publishing Group UK 2023-02-18 /pmc/articles/PMC9938505/ /pubmed/36801948 http://dx.doi.org/10.1038/s41698-023-00361-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Zhang, Shilan
Kapoor, Sabeeta
Tripathi, Chakrapani
Perez, Jorge Tovar
Mohan, Nivedhitha
Dashwood, Wan Mohaiza
Zhang, Ke
Rajendran, Praveen
Dashwood, Roderick
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
title Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
title_full Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
title_fullStr Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
title_full_unstemmed Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
title_short Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
title_sort targeting ace2-brd4 crosstalk in colorectal cancer and the deregulation of dna repair and apoptosis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938505/
https://www.ncbi.nlm.nih.gov/pubmed/36801948
http://dx.doi.org/10.1038/s41698-023-00361-4
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