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Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis

ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis...

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Detalles Bibliográficos
Autores principales:	Zhang, Shilan, Kapoor, Sabeeta, Tripathi, Chakrapani, Perez, Jorge Tovar, Mohan, Nivedhitha, Dashwood, Wan Mohaiza, Zhang, Ke, Rajendran, Praveen, Dashwood, Roderick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938505/ https://www.ncbi.nlm.nih.gov/pubmed/36801948 http://dx.doi.org/10.1038/s41698-023-00361-4

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