Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred,...

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Autores principales: Khosravi, Dara, Soloff, Hannah, Langsjoen, Rose M, Bombin, Andrei, Kelley, Colleen F, Ray, Susan M, Gunthel, Clifford J, Zanoni, Brian C, Nguyen, Phuong-Vi, Waggoner, Jesse J, Wang, Yun F, Cantos, Valeria D, Piantadosi, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938522/
https://www.ncbi.nlm.nih.gov/pubmed/36820315
http://dx.doi.org/10.1093/ofid/ofad054
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author Khosravi, Dara
Soloff, Hannah
Langsjoen, Rose M
Bombin, Andrei
Kelley, Colleen F
Ray, Susan M
Gunthel, Clifford J
Zanoni, Brian C
Nguyen, Phuong-Vi
Waggoner, Jesse J
Wang, Yun F
Cantos, Valeria D
Piantadosi, Anne
author_facet Khosravi, Dara
Soloff, Hannah
Langsjoen, Rose M
Bombin, Andrei
Kelley, Colleen F
Ray, Susan M
Gunthel, Clifford J
Zanoni, Brian C
Nguyen, Phuong-Vi
Waggoner, Jesse J
Wang, Yun F
Cantos, Valeria D
Piantadosi, Anne
author_sort Khosravi, Dara
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.
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spelling pubmed-99385222023-02-19 Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV Khosravi, Dara Soloff, Hannah Langsjoen, Rose M Bombin, Andrei Kelley, Colleen F Ray, Susan M Gunthel, Clifford J Zanoni, Brian C Nguyen, Phuong-Vi Waggoner, Jesse J Wang, Yun F Cantos, Valeria D Piantadosi, Anne Open Forum Infect Dis Brief Report Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received. Oxford University Press 2023-02-03 /pmc/articles/PMC9938522/ /pubmed/36820315 http://dx.doi.org/10.1093/ofid/ofad054 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Khosravi, Dara
Soloff, Hannah
Langsjoen, Rose M
Bombin, Andrei
Kelley, Colleen F
Ray, Susan M
Gunthel, Clifford J
Zanoni, Brian C
Nguyen, Phuong-Vi
Waggoner, Jesse J
Wang, Yun F
Cantos, Valeria D
Piantadosi, Anne
Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV
title Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV
title_full Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV
title_fullStr Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV
title_full_unstemmed Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV
title_short Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV
title_sort severe acute respiratory syndrome coronavirus 2 evolution and escape from combination monoclonal antibody treatment in a person with hiv
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938522/
https://www.ncbi.nlm.nih.gov/pubmed/36820315
http://dx.doi.org/10.1093/ofid/ofad054
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