A Trem2(R47H) mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

BACKGROUND: The TREM2 R47H variant is one of the strongest genetic risk factors for late-onset Alzheimer’s Disease (AD). Unfortunately, many current Trem2 (R47H) mouse models are associated with cryptic mRNA splicing of the mutant allele that produces a confounding reduction in protein product. To o...

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Detalles Bibliográficos
Autores principales: Tran, Kristine M., Kawauchi, Shimako, Kramár, Enikö A., Rezaie, Narges, Liang, Heidi Yahan, Sakr, Jasmine S., Gomez-Arboledas, Angela, Arreola, Miguel A., Cunha, Celia da, Phan, Jimmy, Wang, Shuling, Collins, Sherilyn, Walker, Amber, Shi, Kai-Xuan, Neumann, Jonathan, Filimban, Ghassan, Shi, Zechuan, Milinkeviciute, Giedre, Javonillo, Dominic I., Tran, Katelynn, Gantuz, Magdalena, Forner, Stefania, Swarup, Vivek, Tenner, Andrea J., LaFerla, Frank M., Wood, Marcelo A., Mortazavi, Ali, MacGregor, Grant R., Green, Kim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938579/
https://www.ncbi.nlm.nih.gov/pubmed/36803190
http://dx.doi.org/10.1186/s13024-023-00598-4

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