Cargando…

Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer

BACKGROUND: Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Chi-Chang, Hsu, Chia-Chang, Yu, Teng-Hung, Hung, Wei-Chin, Kuo, Shyh-Ming, Chen, Chia-Chi, Wu, Cheng-Ching, Chung, Fu-Mei, Lee, Yau-Jiunn, Wei, Ching-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938596/
https://www.ncbi.nlm.nih.gov/pubmed/36800961
http://dx.doi.org/10.1186/s12957-023-02944-8
_version_ 1784890665352560640
author Chang, Chi-Chang
Hsu, Chia-Chang
Yu, Teng-Hung
Hung, Wei-Chin
Kuo, Shyh-Ming
Chen, Chia-Chi
Wu, Cheng-Ching
Chung, Fu-Mei
Lee, Yau-Jiunn
Wei, Ching-Ting
author_facet Chang, Chi-Chang
Hsu, Chia-Chang
Yu, Teng-Hung
Hung, Wei-Chin
Kuo, Shyh-Ming
Chen, Chia-Chi
Wu, Cheng-Ching
Chung, Fu-Mei
Lee, Yau-Jiunn
Wei, Ching-Ting
author_sort Chang, Chi-Chang
collection PubMed
description BACKGROUND: Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue. METHOD: A total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry. RESULT: The patients had higher plasma L-FABP levels than the controls (7.6 ng/mL (interquartile range 5.2–12.1) vs. 6.3 ng/mL (interquartile range 5.3–8.5), p = 0.008). Multiple logistic regression analysis showed an independent association between L-FABP and breast cancer, even after adjusting for known biomarkers. Moreover, the rates of pathologic stage T2+T3+T4, clinical stage III, positive HER-2 receptor status, and negative estrogen receptor status were significantly higher in the patients with an L-FABP level greater than the median. Furthermore, the L-FABP level gradually increased with the increasing stage. In addition, L-FABP was detected in the cytoplasm, nuclear, or both cytoplasm and nuclear of all breast cancer tissue examined, not in the normal tissue. CONCLUSIONS: Plasma L-FABP levels were significantly higher in the patients with breast cancer than in the controls. In addition, L-FABP was expressed in breast cancer tissue, which suggests that L-FABP may be involved in the pathogenesis of breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-023-02944-8.
format Online
Article
Text
id pubmed-9938596
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-99385962023-02-19 Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer Chang, Chi-Chang Hsu, Chia-Chang Yu, Teng-Hung Hung, Wei-Chin Kuo, Shyh-Ming Chen, Chia-Chi Wu, Cheng-Ching Chung, Fu-Mei Lee, Yau-Jiunn Wei, Ching-Ting World J Surg Oncol Research BACKGROUND: Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue. METHOD: A total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry. RESULT: The patients had higher plasma L-FABP levels than the controls (7.6 ng/mL (interquartile range 5.2–12.1) vs. 6.3 ng/mL (interquartile range 5.3–8.5), p = 0.008). Multiple logistic regression analysis showed an independent association between L-FABP and breast cancer, even after adjusting for known biomarkers. Moreover, the rates of pathologic stage T2+T3+T4, clinical stage III, positive HER-2 receptor status, and negative estrogen receptor status were significantly higher in the patients with an L-FABP level greater than the median. Furthermore, the L-FABP level gradually increased with the increasing stage. In addition, L-FABP was detected in the cytoplasm, nuclear, or both cytoplasm and nuclear of all breast cancer tissue examined, not in the normal tissue. CONCLUSIONS: Plasma L-FABP levels were significantly higher in the patients with breast cancer than in the controls. In addition, L-FABP was expressed in breast cancer tissue, which suggests that L-FABP may be involved in the pathogenesis of breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-023-02944-8. BioMed Central 2023-02-18 /pmc/articles/PMC9938596/ /pubmed/36800961 http://dx.doi.org/10.1186/s12957-023-02944-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chang, Chi-Chang
Hsu, Chia-Chang
Yu, Teng-Hung
Hung, Wei-Chin
Kuo, Shyh-Ming
Chen, Chia-Chi
Wu, Cheng-Ching
Chung, Fu-Mei
Lee, Yau-Jiunn
Wei, Ching-Ting
Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
title Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
title_full Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
title_fullStr Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
title_full_unstemmed Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
title_short Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
title_sort plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938596/
https://www.ncbi.nlm.nih.gov/pubmed/36800961
http://dx.doi.org/10.1186/s12957-023-02944-8
work_keys_str_mv AT changchichang plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT hsuchiachang plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT yutenghung plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT hungweichin plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT kuoshyhming plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT chenchiachi plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT wuchengching plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT chungfumei plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT leeyaujiunn plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer
AT weichingting plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer