Cargando…
Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
BACKGROUND: Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938596/ https://www.ncbi.nlm.nih.gov/pubmed/36800961 http://dx.doi.org/10.1186/s12957-023-02944-8 |
_version_ | 1784890665352560640 |
---|---|
author | Chang, Chi-Chang Hsu, Chia-Chang Yu, Teng-Hung Hung, Wei-Chin Kuo, Shyh-Ming Chen, Chia-Chi Wu, Cheng-Ching Chung, Fu-Mei Lee, Yau-Jiunn Wei, Ching-Ting |
author_facet | Chang, Chi-Chang Hsu, Chia-Chang Yu, Teng-Hung Hung, Wei-Chin Kuo, Shyh-Ming Chen, Chia-Chi Wu, Cheng-Ching Chung, Fu-Mei Lee, Yau-Jiunn Wei, Ching-Ting |
author_sort | Chang, Chi-Chang |
collection | PubMed |
description | BACKGROUND: Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue. METHOD: A total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry. RESULT: The patients had higher plasma L-FABP levels than the controls (7.6 ng/mL (interquartile range 5.2–12.1) vs. 6.3 ng/mL (interquartile range 5.3–8.5), p = 0.008). Multiple logistic regression analysis showed an independent association between L-FABP and breast cancer, even after adjusting for known biomarkers. Moreover, the rates of pathologic stage T2+T3+T4, clinical stage III, positive HER-2 receptor status, and negative estrogen receptor status were significantly higher in the patients with an L-FABP level greater than the median. Furthermore, the L-FABP level gradually increased with the increasing stage. In addition, L-FABP was detected in the cytoplasm, nuclear, or both cytoplasm and nuclear of all breast cancer tissue examined, not in the normal tissue. CONCLUSIONS: Plasma L-FABP levels were significantly higher in the patients with breast cancer than in the controls. In addition, L-FABP was expressed in breast cancer tissue, which suggests that L-FABP may be involved in the pathogenesis of breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-023-02944-8. |
format | Online Article Text |
id | pubmed-9938596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99385962023-02-19 Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer Chang, Chi-Chang Hsu, Chia-Chang Yu, Teng-Hung Hung, Wei-Chin Kuo, Shyh-Ming Chen, Chia-Chi Wu, Cheng-Ching Chung, Fu-Mei Lee, Yau-Jiunn Wei, Ching-Ting World J Surg Oncol Research BACKGROUND: Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue. METHOD: A total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry. RESULT: The patients had higher plasma L-FABP levels than the controls (7.6 ng/mL (interquartile range 5.2–12.1) vs. 6.3 ng/mL (interquartile range 5.3–8.5), p = 0.008). Multiple logistic regression analysis showed an independent association between L-FABP and breast cancer, even after adjusting for known biomarkers. Moreover, the rates of pathologic stage T2+T3+T4, clinical stage III, positive HER-2 receptor status, and negative estrogen receptor status were significantly higher in the patients with an L-FABP level greater than the median. Furthermore, the L-FABP level gradually increased with the increasing stage. In addition, L-FABP was detected in the cytoplasm, nuclear, or both cytoplasm and nuclear of all breast cancer tissue examined, not in the normal tissue. CONCLUSIONS: Plasma L-FABP levels were significantly higher in the patients with breast cancer than in the controls. In addition, L-FABP was expressed in breast cancer tissue, which suggests that L-FABP may be involved in the pathogenesis of breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-023-02944-8. BioMed Central 2023-02-18 /pmc/articles/PMC9938596/ /pubmed/36800961 http://dx.doi.org/10.1186/s12957-023-02944-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Chang, Chi-Chang Hsu, Chia-Chang Yu, Teng-Hung Hung, Wei-Chin Kuo, Shyh-Ming Chen, Chia-Chi Wu, Cheng-Ching Chung, Fu-Mei Lee, Yau-Jiunn Wei, Ching-Ting Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
title | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
title_full | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
title_fullStr | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
title_full_unstemmed | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
title_short | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
title_sort | plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938596/ https://www.ncbi.nlm.nih.gov/pubmed/36800961 http://dx.doi.org/10.1186/s12957-023-02944-8 |
work_keys_str_mv | AT changchichang plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT hsuchiachang plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT yutenghung plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT hungweichin plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT kuoshyhming plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT chenchiachi plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT wuchengching plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT chungfumei plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT leeyaujiunn plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT weichingting plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer |