Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice

Obesity increases the severity of airway hyperresponsiveness (AHR) in individuals with asthma, but the mechanism is not well elucidated. G-protein coupled receptor 40 (GPR40) has been found to induce airway smooth muscle contraction after activated by long-chain fatty acids (LC-FFAs), suggesting a c...

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Detalles Bibliográficos
Autores principales: Lin, Xixi, Wang, Like, Lu, Xiaojie, Zhang, Yuanyuan, Zheng, Rongying, Chen, Ruijie, Zhang, Weixi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938616/
https://www.ncbi.nlm.nih.gov/pubmed/36803977
http://dx.doi.org/10.1186/s12931-023-02361-1

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