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Skeletal stem cells: origins, definitions, and functions in bone development and disease
Skeletal stem cells (SSCs) are tissue-specific stem cells that can self-renew and sit at the apex of their differentiation hierarchy, giving rise to mature skeletal cell types required for bone growth, maintenance, and repair. Dysfunction in SSCs is caused by stress conditions like ageing and inflam...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938638/ https://www.ncbi.nlm.nih.gov/pubmed/36811112 http://dx.doi.org/10.1093/lifemedi/lnac048 |
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author | Feng, Heng Jiang, Bo Xing, Wenhui Sun, Jun Greenblatt, Matthew B Zou, Weiguo |
author_facet | Feng, Heng Jiang, Bo Xing, Wenhui Sun, Jun Greenblatt, Matthew B Zou, Weiguo |
author_sort | Feng, Heng |
collection | PubMed |
description | Skeletal stem cells (SSCs) are tissue-specific stem cells that can self-renew and sit at the apex of their differentiation hierarchy, giving rise to mature skeletal cell types required for bone growth, maintenance, and repair. Dysfunction in SSCs is caused by stress conditions like ageing and inflammation and is emerging as a contributor to skeletal pathology, such as the pathogenesis of fracture nonunion. Recent lineage tracing experiments have shown that SSCs exist in the bone marrow, periosteum, and resting zone of the growth plate. Unraveling their regulatory networks is crucial for understanding skeletal diseases and developing therapeutic strategies. In this review, we systematically introduce the definition, location, stem cell niches, regulatory signaling pathways, and clinical applications of SSCs. |
format | Online Article Text |
id | pubmed-9938638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99386382023-02-19 Skeletal stem cells: origins, definitions, and functions in bone development and disease Feng, Heng Jiang, Bo Xing, Wenhui Sun, Jun Greenblatt, Matthew B Zou, Weiguo Life Med Review Skeletal stem cells (SSCs) are tissue-specific stem cells that can self-renew and sit at the apex of their differentiation hierarchy, giving rise to mature skeletal cell types required for bone growth, maintenance, and repair. Dysfunction in SSCs is caused by stress conditions like ageing and inflammation and is emerging as a contributor to skeletal pathology, such as the pathogenesis of fracture nonunion. Recent lineage tracing experiments have shown that SSCs exist in the bone marrow, periosteum, and resting zone of the growth plate. Unraveling their regulatory networks is crucial for understanding skeletal diseases and developing therapeutic strategies. In this review, we systematically introduce the definition, location, stem cell niches, regulatory signaling pathways, and clinical applications of SSCs. Oxford University Press 2022-12-08 /pmc/articles/PMC9938638/ /pubmed/36811112 http://dx.doi.org/10.1093/lifemedi/lnac048 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Feng, Heng Jiang, Bo Xing, Wenhui Sun, Jun Greenblatt, Matthew B Zou, Weiguo Skeletal stem cells: origins, definitions, and functions in bone development and disease |
title | Skeletal stem cells: origins, definitions, and functions in bone development and disease |
title_full | Skeletal stem cells: origins, definitions, and functions in bone development and disease |
title_fullStr | Skeletal stem cells: origins, definitions, and functions in bone development and disease |
title_full_unstemmed | Skeletal stem cells: origins, definitions, and functions in bone development and disease |
title_short | Skeletal stem cells: origins, definitions, and functions in bone development and disease |
title_sort | skeletal stem cells: origins, definitions, and functions in bone development and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938638/ https://www.ncbi.nlm.nih.gov/pubmed/36811112 http://dx.doi.org/10.1093/lifemedi/lnac048 |
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