Cargando…

The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study

PURPOSE: The interrelationships among age at menopause, sleep, and brain health have been insufficiently studied. This study sought to examine the influence of age at natural menopause and insomnia symptoms on long-term cognitive function among US women. PATIENTS AND METHODS: Our study included a na...

Descripción completa

Detalles Bibliográficos
Autores principales: Shieu, Monica M, Braley, Tiffany J, Becker, Jill, Dunietz, Galit Levi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938660/
https://www.ncbi.nlm.nih.gov/pubmed/36820129
http://dx.doi.org/10.2147/NSS.S398019
_version_ 1784890680291622912
author Shieu, Monica M
Braley, Tiffany J
Becker, Jill
Dunietz, Galit Levi
author_facet Shieu, Monica M
Braley, Tiffany J
Becker, Jill
Dunietz, Galit Levi
author_sort Shieu, Monica M
collection PubMed
description PURPOSE: The interrelationships among age at menopause, sleep, and brain health have been insufficiently studied. This study sought to examine the influence of age at natural menopause and insomnia symptoms on long-term cognitive function among US women. PATIENTS AND METHODS: Our study included a nationally representative cohort of US adults age 50+ from the Health and Retirement Study (2008–2018). We restricted this cohort to 5880 women age 50+, from a diverse racial and ethnic groups. Age at menopause was retrieved from baseline (2008) for women having natural menopause. Five questions were used to identify women with insomnia symptoms (2010 and 2012): trouble falling asleep, nighttime awakenings, early morning awakenings, feelings of nonrestorative sleep, and use of sleep aids. A battery of four neuropsychological tests was conducted biennially (years) to evaluate cognitive function. Longitudinal associations between age at natural menopause and cognitive function were estimated with mixed effects models with a random intercept. Insomnia symptoms were examined as potential mediators or modifiers in the pathway between age at menopause and cognition. RESULTS: One year earlier in age at menopause was associated with a 0.49 lower mean in composite cognitive score, in any given survey year (adjusted p = 0.002). Earlier age at menopause was associated with higher risk of developing insomnia symptoms (eg, trouble falling asleep OR = 0.97; 95% CI: 0.96, 0.99), and insomnia symptoms were associated with worse cognitive performance (eg, trouble falling asleep, beta = −0.5, p-value = 0.02). Therefore, insomnia symptoms could potentially mediate the association between age at natural menopause and cognition. CONCLUSION: Earlier age at menopause is associated with a lower score in cognitive performance. This association may be mediated by insomnia symptoms. Our findings spotlight that among women who experience early menopause, there is the need for studies of sleep-based interventions to mitigate cognitive decline.
format Online
Article
Text
id pubmed-9938660
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-99386602023-02-19 The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study Shieu, Monica M Braley, Tiffany J Becker, Jill Dunietz, Galit Levi Nat Sci Sleep Original Research PURPOSE: The interrelationships among age at menopause, sleep, and brain health have been insufficiently studied. This study sought to examine the influence of age at natural menopause and insomnia symptoms on long-term cognitive function among US women. PATIENTS AND METHODS: Our study included a nationally representative cohort of US adults age 50+ from the Health and Retirement Study (2008–2018). We restricted this cohort to 5880 women age 50+, from a diverse racial and ethnic groups. Age at menopause was retrieved from baseline (2008) for women having natural menopause. Five questions were used to identify women with insomnia symptoms (2010 and 2012): trouble falling asleep, nighttime awakenings, early morning awakenings, feelings of nonrestorative sleep, and use of sleep aids. A battery of four neuropsychological tests was conducted biennially (years) to evaluate cognitive function. Longitudinal associations between age at natural menopause and cognitive function were estimated with mixed effects models with a random intercept. Insomnia symptoms were examined as potential mediators or modifiers in the pathway between age at menopause and cognition. RESULTS: One year earlier in age at menopause was associated with a 0.49 lower mean in composite cognitive score, in any given survey year (adjusted p = 0.002). Earlier age at menopause was associated with higher risk of developing insomnia symptoms (eg, trouble falling asleep OR = 0.97; 95% CI: 0.96, 0.99), and insomnia symptoms were associated with worse cognitive performance (eg, trouble falling asleep, beta = −0.5, p-value = 0.02). Therefore, insomnia symptoms could potentially mediate the association between age at natural menopause and cognition. CONCLUSION: Earlier age at menopause is associated with a lower score in cognitive performance. This association may be mediated by insomnia symptoms. Our findings spotlight that among women who experience early menopause, there is the need for studies of sleep-based interventions to mitigate cognitive decline. Dove 2023-02-14 /pmc/articles/PMC9938660/ /pubmed/36820129 http://dx.doi.org/10.2147/NSS.S398019 Text en © 2023 Shieu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Shieu, Monica M
Braley, Tiffany J
Becker, Jill
Dunietz, Galit Levi
The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study
title The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study
title_full The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study
title_fullStr The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study
title_full_unstemmed The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study
title_short The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study
title_sort interplay among natural menopause, insomnia, and cognitive health: a population-based study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938660/
https://www.ncbi.nlm.nih.gov/pubmed/36820129
http://dx.doi.org/10.2147/NSS.S398019
work_keys_str_mv AT shieumonicam theinterplayamongnaturalmenopauseinsomniaandcognitivehealthapopulationbasedstudy
AT braleytiffanyj theinterplayamongnaturalmenopauseinsomniaandcognitivehealthapopulationbasedstudy
AT beckerjill theinterplayamongnaturalmenopauseinsomniaandcognitivehealthapopulationbasedstudy
AT dunietzgalitlevi theinterplayamongnaturalmenopauseinsomniaandcognitivehealthapopulationbasedstudy
AT shieumonicam interplayamongnaturalmenopauseinsomniaandcognitivehealthapopulationbasedstudy
AT braleytiffanyj interplayamongnaturalmenopauseinsomniaandcognitivehealthapopulationbasedstudy
AT beckerjill interplayamongnaturalmenopauseinsomniaandcognitivehealthapopulationbasedstudy
AT dunietzgalitlevi interplayamongnaturalmenopauseinsomniaandcognitivehealthapopulationbasedstudy