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Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance

Background This study aimed to determine the relationship between vitamin D levels and β cell function and insulin resistance in patients with diabetes, glucose tolerance disorder, or impaired fasting glucose. Methodology A total of 75 outpatients (55 females and 20 males) between the ages of 30 and...

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Autores principales: Ozcan, Cem, Corapcıoglu, Demet, Cerit, Ethem Turgay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938722/
https://www.ncbi.nlm.nih.gov/pubmed/36820117
http://dx.doi.org/10.7759/cureus.33970
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author Ozcan, Cem
Corapcıoglu, Demet
Cerit, Ethem Turgay
author_facet Ozcan, Cem
Corapcıoglu, Demet
Cerit, Ethem Turgay
author_sort Ozcan, Cem
collection PubMed
description Background This study aimed to determine the relationship between vitamin D levels and β cell function and insulin resistance in patients with diabetes, glucose tolerance disorder, or impaired fasting glucose. Methodology A total of 75 outpatients (55 females and 20 males) between the ages of 30 and 65 years were included in the study. There were 25 healthy individuals, 25 individuals with prediabetes, and 25 individuals with diabetes. The Homeostasis Model Assessment (HOMA) score was used to evaluate insulin resistance. Results The mean levels of vitamin 25(OH)D among the groups included in the study were 35 ± 16.9 nmol/L in the control group, 44.5 ± 34.5 nmol/L in the prediabetes group, and 35.7 ± 13.1 nmol/L in the diabetes group. There were no significant differences. The mean level of vitamin 1.25(OH)(2)D(3 )was 15.95 ± 8 pg/mL in the control group, 18.4 ± 7.5 pg/mL in the prediabetes group, and 21.5 ± 7.9 pg/mL in the diabetes group. While the levels of vitamin 25(OH)D were similar between the groups, the levels of vitamin 1,25(OH)(2)D(3 ) were significantly higher in the diabetes group. Considering all individuals, no significant difference was found between the vitamin 25(OH)D and glucose levels at minutes 0, 30, 60, 90, and 120. While there was a significant positive relationship between the 1,25(OH)(2)D(3) vitamin and glucose levels at minutes 0, 30, 60, and 90, there was no significant relationship between the levels at minute 120. When the 1,25(OH)(2)D(3) vitamin and HOMA insulin resistance and HOMA β scores were compared, a significant positive relationship was found between the 1,25(OH)(2)D(3) vitamin and HOMA β levels. Conclusions In our study, there was no significant difference between the groups (control, prediabetes, and diabetes) in 25(OH)D levels. Similarly, there was no significant relationship between the 25(OH)D levels and insulin sensitivity and resistance between the groups. The positive relationship identified between the 1,25(OH)(2)D(3) vitamin levels and the glucose concentration at minutes 0, 30, 60, and 90 and the higher 1,25(OH)(2)D(3) vitamin levels in the diabetes group compared to the control group in our study can be interpreted as the effort of the organism to prevent glucose-induced β-cell apoptosis.
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spelling pubmed-99387222023-02-19 Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance Ozcan, Cem Corapcıoglu, Demet Cerit, Ethem Turgay Cureus Endocrinology/Diabetes/Metabolism Background This study aimed to determine the relationship between vitamin D levels and β cell function and insulin resistance in patients with diabetes, glucose tolerance disorder, or impaired fasting glucose. Methodology A total of 75 outpatients (55 females and 20 males) between the ages of 30 and 65 years were included in the study. There were 25 healthy individuals, 25 individuals with prediabetes, and 25 individuals with diabetes. The Homeostasis Model Assessment (HOMA) score was used to evaluate insulin resistance. Results The mean levels of vitamin 25(OH)D among the groups included in the study were 35 ± 16.9 nmol/L in the control group, 44.5 ± 34.5 nmol/L in the prediabetes group, and 35.7 ± 13.1 nmol/L in the diabetes group. There were no significant differences. The mean level of vitamin 1.25(OH)(2)D(3 )was 15.95 ± 8 pg/mL in the control group, 18.4 ± 7.5 pg/mL in the prediabetes group, and 21.5 ± 7.9 pg/mL in the diabetes group. While the levels of vitamin 25(OH)D were similar between the groups, the levels of vitamin 1,25(OH)(2)D(3 ) were significantly higher in the diabetes group. Considering all individuals, no significant difference was found between the vitamin 25(OH)D and glucose levels at minutes 0, 30, 60, 90, and 120. While there was a significant positive relationship between the 1,25(OH)(2)D(3) vitamin and glucose levels at minutes 0, 30, 60, and 90, there was no significant relationship between the levels at minute 120. When the 1,25(OH)(2)D(3) vitamin and HOMA insulin resistance and HOMA β scores were compared, a significant positive relationship was found between the 1,25(OH)(2)D(3) vitamin and HOMA β levels. Conclusions In our study, there was no significant difference between the groups (control, prediabetes, and diabetes) in 25(OH)D levels. Similarly, there was no significant relationship between the 25(OH)D levels and insulin sensitivity and resistance between the groups. The positive relationship identified between the 1,25(OH)(2)D(3) vitamin levels and the glucose concentration at minutes 0, 30, 60, and 90 and the higher 1,25(OH)(2)D(3) vitamin levels in the diabetes group compared to the control group in our study can be interpreted as the effort of the organism to prevent glucose-induced β-cell apoptosis. Cureus 2023-01-19 /pmc/articles/PMC9938722/ /pubmed/36820117 http://dx.doi.org/10.7759/cureus.33970 Text en Copyright © 2023, Ozcan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Ozcan, Cem
Corapcıoglu, Demet
Cerit, Ethem Turgay
Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance
title Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance
title_full Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance
title_fullStr Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance
title_full_unstemmed Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance
title_short Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance
title_sort relationship between vitamin d levels and β cell function and insulin resistance
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938722/
https://www.ncbi.nlm.nih.gov/pubmed/36820117
http://dx.doi.org/10.7759/cureus.33970
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