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Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion

BACKGROUND AND AIMS: Complement activation is essential for tuberculosis pleural effusion. However, little is known about the value of complement regulatory protein (CD46, CD55, and CD59) in the differential diagnosis of tuberculosis. MATERIALS AND METHODS: Ninety-nine patients with exudative pleura...

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Autores principales: Tang, Huan, Hu, Xinyue, Li, Li, Deng, Shuanglinzi, Jiang, Yuanyuan, Luo, Lisha, Cai, Runjin, Yang, Yifei, Wu, Chendong, Gong, Xiaoxiao, Feng, Juntao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938761/
https://www.ncbi.nlm.nih.gov/pubmed/36820087
http://dx.doi.org/10.3389/fimmu.2023.1073884
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author Tang, Huan
Hu, Xinyue
Li, Li
Deng, Shuanglinzi
Jiang, Yuanyuan
Luo, Lisha
Cai, Runjin
Yang, Yifei
Wu, Chendong
Gong, Xiaoxiao
Feng, Juntao
author_facet Tang, Huan
Hu, Xinyue
Li, Li
Deng, Shuanglinzi
Jiang, Yuanyuan
Luo, Lisha
Cai, Runjin
Yang, Yifei
Wu, Chendong
Gong, Xiaoxiao
Feng, Juntao
author_sort Tang, Huan
collection PubMed
description BACKGROUND AND AIMS: Complement activation is essential for tuberculosis pleural effusion. However, little is known about the value of complement regulatory protein (CD46, CD55, and CD59) in the differential diagnosis of tuberculosis. MATERIALS AND METHODS: Ninety-nine patients with exudative pleural effusion admitted to Xiangya Hospital of Central South University from June 1, 2021to November 14, 2022 were enrolled. The expression levels of soluble CD46 (sCD46), soluble CD55 (sCD55), and soluble CD59 (sCD59) in pleural effusion were quantified by enzyme-linked immunosorbent assay, and the receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic and co-diagnostic values. RESULTS: The ADA level is higher in TPE patients than non-TPE patients. It is well-found that TPE patients had lower levels of sCD46, sCD55, and sCD59 compared with non-TPE patients. Moreover, the expression of sCD46, sCD55, and sCD59 in pleural effusion was negatively correlated with ADA. In addition, the diagnostic efficacy of sCD46, sCD55 and sCD59 was comparable to that of ADA, with 0.896, 0.857, 0.858 and 0.893, respectively. Furthermore, combine detection of sCD46, sCD55, sCD59 and ADA could improve the diagnostic accuracy. CONCLUSIONS: Complement regulatory factors (CD46, CD55, and CD59) were validated by this project to be promising candidate biomarkers for the diagnosis of TPE with high accuracy. The combination of the CD46, CD55, and CD59 and ADA assay exist a better diagnostic value in TPE.
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spelling pubmed-99387612023-02-19 Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion Tang, Huan Hu, Xinyue Li, Li Deng, Shuanglinzi Jiang, Yuanyuan Luo, Lisha Cai, Runjin Yang, Yifei Wu, Chendong Gong, Xiaoxiao Feng, Juntao Front Immunol Immunology BACKGROUND AND AIMS: Complement activation is essential for tuberculosis pleural effusion. However, little is known about the value of complement regulatory protein (CD46, CD55, and CD59) in the differential diagnosis of tuberculosis. MATERIALS AND METHODS: Ninety-nine patients with exudative pleural effusion admitted to Xiangya Hospital of Central South University from June 1, 2021to November 14, 2022 were enrolled. The expression levels of soluble CD46 (sCD46), soluble CD55 (sCD55), and soluble CD59 (sCD59) in pleural effusion were quantified by enzyme-linked immunosorbent assay, and the receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic and co-diagnostic values. RESULTS: The ADA level is higher in TPE patients than non-TPE patients. It is well-found that TPE patients had lower levels of sCD46, sCD55, and sCD59 compared with non-TPE patients. Moreover, the expression of sCD46, sCD55, and sCD59 in pleural effusion was negatively correlated with ADA. In addition, the diagnostic efficacy of sCD46, sCD55 and sCD59 was comparable to that of ADA, with 0.896, 0.857, 0.858 and 0.893, respectively. Furthermore, combine detection of sCD46, sCD55, sCD59 and ADA could improve the diagnostic accuracy. CONCLUSIONS: Complement regulatory factors (CD46, CD55, and CD59) were validated by this project to be promising candidate biomarkers for the diagnosis of TPE with high accuracy. The combination of the CD46, CD55, and CD59 and ADA assay exist a better diagnostic value in TPE. Frontiers Media S.A. 2023-02-03 /pmc/articles/PMC9938761/ /pubmed/36820087 http://dx.doi.org/10.3389/fimmu.2023.1073884 Text en Copyright © 2023 Tang, Hu, Li, Deng, Jiang, Luo, Cai, Yang, Wu, Gong and Feng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tang, Huan
Hu, Xinyue
Li, Li
Deng, Shuanglinzi
Jiang, Yuanyuan
Luo, Lisha
Cai, Runjin
Yang, Yifei
Wu, Chendong
Gong, Xiaoxiao
Feng, Juntao
Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion
title Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion
title_full Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion
title_fullStr Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion
title_full_unstemmed Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion
title_short Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion
title_sort complement regulatory proteins: candidate biomarkers in differentiating tuberculosis pleural effusion
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938761/
https://www.ncbi.nlm.nih.gov/pubmed/36820087
http://dx.doi.org/10.3389/fimmu.2023.1073884
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