Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Determination of the mammary epithelial cell that serves as the cell of origin for breast cancer is key to understand tumor heterogeneity and clinical management. In this study, we aimed to decipher whether Rank expression in the presence of PyMT and Neu oncogenes might affect the cell of origin of...

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Detalles Bibliográficos
Autores principales: Cordero, Alex, Santamaría, Patricia G., González-Suárez, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938814/
https://www.ncbi.nlm.nih.gov/pubmed/36808257
http://dx.doi.org/10.1007/s10911-023-09530-4
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author Cordero, Alex
Santamaría, Patricia G.
González-Suárez, Eva
author_facet Cordero, Alex
Santamaría, Patricia G.
González-Suárez, Eva
author_sort Cordero, Alex
collection PubMed
description Determination of the mammary epithelial cell that serves as the cell of origin for breast cancer is key to understand tumor heterogeneity and clinical management. In this study, we aimed to decipher whether Rank expression in the presence of PyMT and Neu oncogenes might affect the cell of origin of mammary gland tumors. We observed that Rank expression in PyMT(+/−) and Neu(+/−) mammary glands alters the basal and luminal mammary cell populations already in preneoplasic tissue, which may interfere with the tumor cell of origin restricting their tumorigenesis ability upon transplantation assays. In spite of this, Rank expression eventually promotes tumor aggressiveness once tumorigenesis is established. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10911-023-09530-4.
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spelling pubmed-99388142023-02-20 Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential Cordero, Alex Santamaría, Patricia G. González-Suárez, Eva J Mammary Gland Biol Neoplasia Original Article Determination of the mammary epithelial cell that serves as the cell of origin for breast cancer is key to understand tumor heterogeneity and clinical management. In this study, we aimed to decipher whether Rank expression in the presence of PyMT and Neu oncogenes might affect the cell of origin of mammary gland tumors. We observed that Rank expression in PyMT(+/−) and Neu(+/−) mammary glands alters the basal and luminal mammary cell populations already in preneoplasic tissue, which may interfere with the tumor cell of origin restricting their tumorigenesis ability upon transplantation assays. In spite of this, Rank expression eventually promotes tumor aggressiveness once tumorigenesis is established. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10911-023-09530-4. Springer US 2023-02-18 2023 /pmc/articles/PMC9938814/ /pubmed/36808257 http://dx.doi.org/10.1007/s10911-023-09530-4 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Cordero, Alex
Santamaría, Patricia G.
González-Suárez, Eva
Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
title Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
title_full Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
title_fullStr Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
title_full_unstemmed Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
title_short Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
title_sort rank ectopic expression in the presence of neu and pymt oncogenes alters mammary epithelial cell populations and their tumorigenic potential
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938814/
https://www.ncbi.nlm.nih.gov/pubmed/36808257
http://dx.doi.org/10.1007/s10911-023-09530-4
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