Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM

Connexin family proteins assemble into hexameric hemichannels in the cell membrane. The hemichannels dock together between two adjacent membranes to form gap junction intercellular channels (GJIChs). We report the cryo-electron microscopy structures of Cx43 GJICh, revealing the dynamic equilibrium s...

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Detalles Bibliográficos
Autores principales: Lee, Hyuk-Joon, Cha, Hyung Jin, Jeong, Hyeongseop, Lee, Seu-Na, Lee, Chang-Won, Kim, Minsoo, Yoo, Jejoong, Woo, Jae-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938869/
https://www.ncbi.nlm.nih.gov/pubmed/36805660
http://dx.doi.org/10.1038/s41467-023-36593-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938869/
https://www.ncbi.nlm.nih.gov/pubmed/36805660
http://dx.doi.org/10.1038/s41467-023-36593-y

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