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Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment
Compressive knee joint contact force during walking is thought to be related to initiation and progression of knee osteoarthritis. However, joint loading is often evaluated with surrogate measures, like the external knee adduction moment, due to the complexity of computing joint contact forces. Stat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938879/ https://www.ncbi.nlm.nih.gov/pubmed/36806297 http://dx.doi.org/10.1038/s41598-023-30058-4 |
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author | Holder, Jana van Drongelen, Stefan Uhlrich, Scott David Herrmann, Eva Meurer, Andrea Stief, Felix |
author_facet | Holder, Jana van Drongelen, Stefan Uhlrich, Scott David Herrmann, Eva Meurer, Andrea Stief, Felix |
author_sort | Holder, Jana |
collection | PubMed |
description | Compressive knee joint contact force during walking is thought to be related to initiation and progression of knee osteoarthritis. However, joint loading is often evaluated with surrogate measures, like the external knee adduction moment, due to the complexity of computing joint contact forces. Statistical models have shown promising correlations between medial knee joint contact forces and knee adduction moments in particularly in individuals with knee osteoarthritis or after total knee replacements (R(2) = 0.44–0.60). The purpose of this study was to evaluate how accurately model-based predictions of peak medial and lateral knee joint contact forces during walking could be estimated by linear mixed-effects models including joint moments for children and adolescents with and without valgus malalignment. Peak knee joint moments were strongly correlated (R(2) > 0.85, p < 0.001) with both peak medial and lateral knee joint contact forces. The knee flexion and adduction moments were significant covariates in the models, strengthening the understanding of the statistical relationship between both moments and medial and lateral knee joint contact forces. In the future, these models could be used to evaluate peak knee joint contact forces from musculoskeletal simulations using peak joint moments from motion capture software, obviating the need for time-consuming musculoskeletal simulations. |
format | Online Article Text |
id | pubmed-9938879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99388792023-02-20 Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment Holder, Jana van Drongelen, Stefan Uhlrich, Scott David Herrmann, Eva Meurer, Andrea Stief, Felix Sci Rep Article Compressive knee joint contact force during walking is thought to be related to initiation and progression of knee osteoarthritis. However, joint loading is often evaluated with surrogate measures, like the external knee adduction moment, due to the complexity of computing joint contact forces. Statistical models have shown promising correlations between medial knee joint contact forces and knee adduction moments in particularly in individuals with knee osteoarthritis or after total knee replacements (R(2) = 0.44–0.60). The purpose of this study was to evaluate how accurately model-based predictions of peak medial and lateral knee joint contact forces during walking could be estimated by linear mixed-effects models including joint moments for children and adolescents with and without valgus malalignment. Peak knee joint moments were strongly correlated (R(2) > 0.85, p < 0.001) with both peak medial and lateral knee joint contact forces. The knee flexion and adduction moments were significant covariates in the models, strengthening the understanding of the statistical relationship between both moments and medial and lateral knee joint contact forces. In the future, these models could be used to evaluate peak knee joint contact forces from musculoskeletal simulations using peak joint moments from motion capture software, obviating the need for time-consuming musculoskeletal simulations. Nature Publishing Group UK 2023-02-18 /pmc/articles/PMC9938879/ /pubmed/36806297 http://dx.doi.org/10.1038/s41598-023-30058-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Holder, Jana van Drongelen, Stefan Uhlrich, Scott David Herrmann, Eva Meurer, Andrea Stief, Felix Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment |
title | Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment |
title_full | Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment |
title_fullStr | Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment |
title_full_unstemmed | Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment |
title_short | Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment |
title_sort | peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938879/ https://www.ncbi.nlm.nih.gov/pubmed/36806297 http://dx.doi.org/10.1038/s41598-023-30058-4 |
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