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BRAF v600E–mutant cancers treated with vemurafenib alone or in combination with everolimus, sorafenib, or crizotinib or with paclitaxel and carboplatin (VEM-PLUS) study

Combined BRAF + MEK inhibition is FDA approved for BRAF V600E-mutant solid tumors except for colorectal cancer. However, beyond MAPK mediated resistance several other mechanisms of resistance such as activation of CRAF, ARAF, MET, P13K/AKT/mTOR pathway exist among other complex pathways. In the VEM-...

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Detalles Bibliográficos
Autores principales:	Nelson, Blessie Elizabeth, Roszik, Jason, Janku, Filip, Hong, David S., Kato, Shumei, Naing, Aung, Piha-Paul, Sarina, Fu, Siqing, Tsimberidou, Apostolia, Cabanillas, Maria, Busaidy, Naifa Lamki, Javle, Milind, Byers, Lauren Averett, Heymach, John V., Meric-Bernstam, Funda, Subbiah, Vivek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938883/ https://www.ncbi.nlm.nih.gov/pubmed/36801912 http://dx.doi.org/10.1038/s41698-022-00341-0

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