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Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens

Type IA topoisomerases maintain DNA topology by cleaving ssDNA and relaxing negative supercoils. The inhibition of its activity in bacteria prevents the relaxation of negative supercoils, which in turn impedes DNA metabolic processes leading to cell death. Using this hypothesis, two bisbenzimidazole...

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Detalles Bibliográficos
Autores principales:	Maurya, Vikas, Singh, Raja, Singh, Reman Kumar, Pandey, Stuti, Yadav, Pooja, Parashar, Palak, Gaind, Rajni, Dubey, Kshatresh Dutta, Naresh Patwari, G., Tandon, Vibha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938908/ https://www.ncbi.nlm.nih.gov/pubmed/36807602 http://dx.doi.org/10.1038/s42003-023-04412-1

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