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Insights Into The Effects of Amino Acid Substitutions on The Stability of Reteplase Structure: A Molecular Dynamics Simulation Study

BACKGROUND: Reteplase (recombinant plasminogen activator, r-PA) is a recombinant protein designed to imitate the endogenous tissue plasminogen activator and catalyze the plasmin production. It is known that the application of reteplase is limited by the complex production processes and protein’s sta...

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Detalles Bibliográficos
Autores principales:	Haji-Allahverdipoor, Kaveh, Jalali Javaran, Mokhtar, Rashidi Monfared, Sajad, Khadem-Erfan, Mohamad Bagher, Nikkhoo, Bahram, Bahrami Rad, Zhila, Eslami, Habib, Nasseri, Sherko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Institute of Genetic Engineering and Biotechnology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938932/ https://www.ncbi.nlm.nih.gov/pubmed/36811105 http://dx.doi.org/10.30498/ijb.2022.308798.3175

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