Cargando…

Sex disparities in the association between acute myocardial infarction and colon cancer risk

BACKGROUND: Acute myocardial infarction (AMI) and colon cancer share similar risk factors. Studies have suggested an association between AMI and colon cancer; however, evidence is conflicting. Whether sex disparities exist in this association in the real world remains unknown. METHODS: In this popul...

Descripción completa

Detalles Bibliográficos
Autores principales: Chou, Shing‐Hsien, Lin, Chia‐Pin, Lin, Yu‐Sheng, Lee, Ting‐Hein, Yang, Chan‐Keng, Chu, Pao‐Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939112/
https://www.ncbi.nlm.nih.gov/pubmed/36069126
http://dx.doi.org/10.1002/cam4.5205
_version_ 1784890773853962240
author Chou, Shing‐Hsien
Lin, Chia‐Pin
Lin, Yu‐Sheng
Lee, Ting‐Hein
Yang, Chan‐Keng
Lin, Yu‐Sheng
Chu, Pao‐Hsien
author_facet Chou, Shing‐Hsien
Lin, Chia‐Pin
Lin, Yu‐Sheng
Lee, Ting‐Hein
Yang, Chan‐Keng
Lin, Yu‐Sheng
Chu, Pao‐Hsien
author_sort Chou, Shing‐Hsien
collection PubMed
description BACKGROUND: Acute myocardial infarction (AMI) and colon cancer share similar risk factors. Studies have suggested an association between AMI and colon cancer; however, evidence is conflicting. Whether sex disparities exist in this association in the real world remains unknown. METHODS: In this population‐based retrospective cohort study, 94,780 and 97,987 male patients and 38,697 and 72,007 female patients with and without new‐onset AMI, respectively, from January 1, 2001, to December 31, 2012, were enrolled from Taiwan's National Health Insurance Research Database. Inverse probability of treatment weighting (IPTW) was used to balance covariates across study groups. The primary outcome was a new diagnosis of colon cancer. RESULTS: The incidence rate of colon cancer was 1.54 (95% confidence interval [CI] = 1.46–1.62) and 1.40 (95% CI = 1.32–1.48) per 1000 person‐years in the male patients and 1.62 (95% CI = 1.50–1.74) and 1.22 (95% CI = 1.13–1.32) in the female patients, in the AMI and non‐AMI groups, respectively. AMI was associated with a significantly higher risk of colon cancer in the female patients (hazard ratio [HR] = 1.31, 95% CI = 1.06–1.61) but not in the male patients (HR = 1.09, 95% CI = 0.95–1.26). In the subgroup analysis, the association between AMI and colon cancer in the female patients was stronger in those aged ≥65 years (HR = 1.28, 95% CI = 1.13–1.44). CONCLUSIONS: An increased risk of colon cancer was observed only in the female patients with AMI. The association between AMI and colon cancer in the female patients was the most evident in those aged ≥65 years.
format Online
Article
Text
id pubmed-9939112
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-99391122023-02-20 Sex disparities in the association between acute myocardial infarction and colon cancer risk Chou, Shing‐Hsien Lin, Chia‐Pin Lin, Yu‐Sheng Lee, Ting‐Hein Yang, Chan‐Keng Lin, Yu‐Sheng Chu, Pao‐Hsien Cancer Med RESEARCH ARTICLES BACKGROUND: Acute myocardial infarction (AMI) and colon cancer share similar risk factors. Studies have suggested an association between AMI and colon cancer; however, evidence is conflicting. Whether sex disparities exist in this association in the real world remains unknown. METHODS: In this population‐based retrospective cohort study, 94,780 and 97,987 male patients and 38,697 and 72,007 female patients with and without new‐onset AMI, respectively, from January 1, 2001, to December 31, 2012, were enrolled from Taiwan's National Health Insurance Research Database. Inverse probability of treatment weighting (IPTW) was used to balance covariates across study groups. The primary outcome was a new diagnosis of colon cancer. RESULTS: The incidence rate of colon cancer was 1.54 (95% confidence interval [CI] = 1.46–1.62) and 1.40 (95% CI = 1.32–1.48) per 1000 person‐years in the male patients and 1.62 (95% CI = 1.50–1.74) and 1.22 (95% CI = 1.13–1.32) in the female patients, in the AMI and non‐AMI groups, respectively. AMI was associated with a significantly higher risk of colon cancer in the female patients (hazard ratio [HR] = 1.31, 95% CI = 1.06–1.61) but not in the male patients (HR = 1.09, 95% CI = 0.95–1.26). In the subgroup analysis, the association between AMI and colon cancer in the female patients was stronger in those aged ≥65 years (HR = 1.28, 95% CI = 1.13–1.44). CONCLUSIONS: An increased risk of colon cancer was observed only in the female patients with AMI. The association between AMI and colon cancer in the female patients was the most evident in those aged ≥65 years. John Wiley and Sons Inc. 2022-09-07 /pmc/articles/PMC9939112/ /pubmed/36069126 http://dx.doi.org/10.1002/cam4.5205 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Chou, Shing‐Hsien
Lin, Chia‐Pin
Lin, Yu‐Sheng
Lee, Ting‐Hein
Yang, Chan‐Keng
Lin, Yu‐Sheng
Chu, Pao‐Hsien
Sex disparities in the association between acute myocardial infarction and colon cancer risk
title Sex disparities in the association between acute myocardial infarction and colon cancer risk
title_full Sex disparities in the association between acute myocardial infarction and colon cancer risk
title_fullStr Sex disparities in the association between acute myocardial infarction and colon cancer risk
title_full_unstemmed Sex disparities in the association between acute myocardial infarction and colon cancer risk
title_short Sex disparities in the association between acute myocardial infarction and colon cancer risk
title_sort sex disparities in the association between acute myocardial infarction and colon cancer risk
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939112/
https://www.ncbi.nlm.nih.gov/pubmed/36069126
http://dx.doi.org/10.1002/cam4.5205
work_keys_str_mv AT choushinghsien sexdisparitiesintheassociationbetweenacutemyocardialinfarctionandcoloncancerrisk
AT linchiapin sexdisparitiesintheassociationbetweenacutemyocardialinfarctionandcoloncancerrisk
AT linyusheng sexdisparitiesintheassociationbetweenacutemyocardialinfarctionandcoloncancerrisk
AT leetinghein sexdisparitiesintheassociationbetweenacutemyocardialinfarctionandcoloncancerrisk
AT yangchankeng sexdisparitiesintheassociationbetweenacutemyocardialinfarctionandcoloncancerrisk
AT linyusheng sexdisparitiesintheassociationbetweenacutemyocardialinfarctionandcoloncancerrisk
AT chupaohsien sexdisparitiesintheassociationbetweenacutemyocardialinfarctionandcoloncancerrisk