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Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide

Enzalutamide, apalutamide, and darolutamide are currently recommended for patients with non‐metastatic castration‐resistant prostate cancer (nmCRPC), but cross‐resistance of androgen receptor‐axis‐targeted therapies (ARAT) occurs. Because darolutamide has a distinct chemical structure to other non‐s...

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Autores principales: Fujmoto, Saizo, Fujita, Kazutoshi, Nishimoto, Mitsuhisa, Hamaguchi, Mamoru, Kuwahara, Ken, Hashimoto, Mamoru, Adomi, Shogo, Minami, Takafumi, Nozawa, Masahiro, Yoshimura, Kazuhiro, Uemura, Hirotsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939194/
https://www.ncbi.nlm.nih.gov/pubmed/36043427
http://dx.doi.org/10.1002/cam4.5189
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author Fujmoto, Saizo
Fujita, Kazutoshi
Nishimoto, Mitsuhisa
Hamaguchi, Mamoru
Kuwahara, Ken
Hashimoto, Mamoru
Adomi, Shogo
Minami, Takafumi
Nozawa, Masahiro
Yoshimura, Kazuhiro
Uemura, Hirotsugu
author_facet Fujmoto, Saizo
Fujita, Kazutoshi
Nishimoto, Mitsuhisa
Hamaguchi, Mamoru
Kuwahara, Ken
Hashimoto, Mamoru
Adomi, Shogo
Minami, Takafumi
Nozawa, Masahiro
Yoshimura, Kazuhiro
Uemura, Hirotsugu
author_sort Fujmoto, Saizo
collection PubMed
description Enzalutamide, apalutamide, and darolutamide are currently recommended for patients with non‐metastatic castration‐resistant prostate cancer (nmCRPC), but cross‐resistance of androgen receptor‐axis‐targeted therapies (ARAT) occurs. Because darolutamide has a distinct chemical structure to other non‐steroidal antiandrogens, it may be effective for nmCRPC patients resistant to enzalutamide or apalutamide. We retrospectively evaluated the efficacy of switching to darolutamide in patients with nmCRPC. We included nine nmCRPC patients who experienced biochemical progression on enzalutamide or apalutamide and were switched over to darolutamide. Five patients (55.5%) had a PSA response >50% decline after starting darolutamide, with an average of 73% PSA decline. Median progression‐free survival was 6 months. In conclusion, an ARAT switch from enzalutamide or apalutamide to darolutamide might be effective for nmCRPC. Although the validation in a large‐scale cohort is necessary, the switch to darolutamide could be a promising therapeutic option after the progression of 1st line ARAT in nmCRPC patients.
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spelling pubmed-99391942023-02-20 Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide Fujmoto, Saizo Fujita, Kazutoshi Nishimoto, Mitsuhisa Hamaguchi, Mamoru Kuwahara, Ken Hashimoto, Mamoru Adomi, Shogo Minami, Takafumi Nozawa, Masahiro Yoshimura, Kazuhiro Uemura, Hirotsugu Cancer Med BRIEF COMMUNICATION Enzalutamide, apalutamide, and darolutamide are currently recommended for patients with non‐metastatic castration‐resistant prostate cancer (nmCRPC), but cross‐resistance of androgen receptor‐axis‐targeted therapies (ARAT) occurs. Because darolutamide has a distinct chemical structure to other non‐steroidal antiandrogens, it may be effective for nmCRPC patients resistant to enzalutamide or apalutamide. We retrospectively evaluated the efficacy of switching to darolutamide in patients with nmCRPC. We included nine nmCRPC patients who experienced biochemical progression on enzalutamide or apalutamide and were switched over to darolutamide. Five patients (55.5%) had a PSA response >50% decline after starting darolutamide, with an average of 73% PSA decline. Median progression‐free survival was 6 months. In conclusion, an ARAT switch from enzalutamide or apalutamide to darolutamide might be effective for nmCRPC. Although the validation in a large‐scale cohort is necessary, the switch to darolutamide could be a promising therapeutic option after the progression of 1st line ARAT in nmCRPC patients. John Wiley and Sons Inc. 2022-08-31 /pmc/articles/PMC9939194/ /pubmed/36043427 http://dx.doi.org/10.1002/cam4.5189 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle BRIEF COMMUNICATION
Fujmoto, Saizo
Fujita, Kazutoshi
Nishimoto, Mitsuhisa
Hamaguchi, Mamoru
Kuwahara, Ken
Hashimoto, Mamoru
Adomi, Shogo
Minami, Takafumi
Nozawa, Masahiro
Yoshimura, Kazuhiro
Uemura, Hirotsugu
Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide
title Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide
title_full Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide
title_fullStr Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide
title_full_unstemmed Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide
title_short Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide
title_sort sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide
topic BRIEF COMMUNICATION
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939194/
https://www.ncbi.nlm.nih.gov/pubmed/36043427
http://dx.doi.org/10.1002/cam4.5189
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