Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM), a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes, accounts for 20% of sudden cardiac death and lacks effective treatment. It is often caused by mutations in desmosome proteins, with Desmoglein-2 (DSG2) mutations as a common e...

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Detalles Bibliográficos
Autores principales: Lin, Yubi, Liu, Ruonan, Huang, Yanling, Yang, Zhe, Xian, Jianzhong, Huang, Jingmin, Qiu, Zirui, Lin, Xiufang, Zhang, Mengzhen, Chen, Hui, Wang, Huadong, Huang, Jiana, Xu, Geyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939300/
https://www.ncbi.nlm.nih.gov/pubmed/36815030
http://dx.doi.org/10.1016/j.apsb.2022.05.018

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