Structure–activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M(4)

There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor 4 (M(4)) in schizophrenia and dementia with Lewy bodies, however, a clinically validated M(4) positron emission tomography (PET) radioligand is currently lacking. As such, the aim of this study was to develop...

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Detalles Bibliográficos
Autores principales: Haider, Ahmed, Deng, Xiaoyun, Mastromihalis, Olivia, Pfister, Stefanie K., Jeppesen, Troels E., Xiao, Zhiwei, Pham, Vi, Sun, Shaofa, Rong, Jian, Zhao, Chunyu, Chen, Jiahui, Li, Yinlong, Connors, Theresa R., Davenport, April T., Daunais, James B., Hosseini, Vahid, Ran, Wenqing, Christopoulos, Arthur, Wang, Lu, Valant, Celine, Liang, Steven H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939360/
https://www.ncbi.nlm.nih.gov/pubmed/36815036
http://dx.doi.org/10.1016/j.apsb.2022.07.008

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