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Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice
INTRODUCTION: Kiwifruit (Actinidia chinensis) has rich nutritious and medicinal properties. It is widely consumed worldwide for the intervention of metabolism disorders, however, the underlying mechanism remains unclear. Acrylamide, a well-known toxic ingredient, mainly forms in high-temperature pro...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939636/ https://www.ncbi.nlm.nih.gov/pubmed/36814509 http://dx.doi.org/10.3389/fnut.2023.1080825 |
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author | Chen, Mengyin Chen, Xuefeng Wang, Ketang Cai, Luyang Liu, Nannan Zhou, Duan Jia, Wei Gong, Pin Liu, Ning Sun, Yujiao |
author_facet | Chen, Mengyin Chen, Xuefeng Wang, Ketang Cai, Luyang Liu, Nannan Zhou, Duan Jia, Wei Gong, Pin Liu, Ning Sun, Yujiao |
author_sort | Chen, Mengyin |
collection | PubMed |
description | INTRODUCTION: Kiwifruit (Actinidia chinensis) has rich nutritious and medicinal properties. It is widely consumed worldwide for the intervention of metabolism disorders, however, the underlying mechanism remains unclear. Acrylamide, a well-known toxic ingredient, mainly forms in high-temperature processed carbohydrate-rich food and causes disorders of gut microbiota and systemic metabolism. METHODS: This study explored the protective effects and underlying mechanisms of kiwifruit polysaccharides against acrylamide-induced disorders of gut microbiota and systemic metabolism by measuring the changes of gut microbiota and serum metabolites in mice. RESULTS: The results showed that kiwifruit polysaccharides remarkably alleviated acrylamide-induced toxicity in mice by improving their body features, histopathologic morphology of the liver, and decreased activities of liver function enzymes. Furthermore, the treatment restored the healthy gut microbiota of mice by improving the microbial diversity and abundance of beneficial bacteria such as Lactobacillus. Metabolomics analysis revealed the positive effects of kiwifruit polysaccharides mainly occurred through amino and bile acid-related metabolism pathways including nicotinate and nicotinamide metabolism, primary bile acid biosynthesis, and alanine, aspartate and glutamate metabolism. Additionally, correlation analysis indicated that Lactobacillus exhibited a highly significant correlation with critical metabolites of bile acid metabolism. DISCUSSION: Concisely, kiwifruit polysaccharides may protect against acrylamide-induced toxicity by regulating gut microbiota and metabolism. |
format | Online Article Text |
id | pubmed-9939636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99396362023-02-21 Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice Chen, Mengyin Chen, Xuefeng Wang, Ketang Cai, Luyang Liu, Nannan Zhou, Duan Jia, Wei Gong, Pin Liu, Ning Sun, Yujiao Front Nutr Nutrition INTRODUCTION: Kiwifruit (Actinidia chinensis) has rich nutritious and medicinal properties. It is widely consumed worldwide for the intervention of metabolism disorders, however, the underlying mechanism remains unclear. Acrylamide, a well-known toxic ingredient, mainly forms in high-temperature processed carbohydrate-rich food and causes disorders of gut microbiota and systemic metabolism. METHODS: This study explored the protective effects and underlying mechanisms of kiwifruit polysaccharides against acrylamide-induced disorders of gut microbiota and systemic metabolism by measuring the changes of gut microbiota and serum metabolites in mice. RESULTS: The results showed that kiwifruit polysaccharides remarkably alleviated acrylamide-induced toxicity in mice by improving their body features, histopathologic morphology of the liver, and decreased activities of liver function enzymes. Furthermore, the treatment restored the healthy gut microbiota of mice by improving the microbial diversity and abundance of beneficial bacteria such as Lactobacillus. Metabolomics analysis revealed the positive effects of kiwifruit polysaccharides mainly occurred through amino and bile acid-related metabolism pathways including nicotinate and nicotinamide metabolism, primary bile acid biosynthesis, and alanine, aspartate and glutamate metabolism. Additionally, correlation analysis indicated that Lactobacillus exhibited a highly significant correlation with critical metabolites of bile acid metabolism. DISCUSSION: Concisely, kiwifruit polysaccharides may protect against acrylamide-induced toxicity by regulating gut microbiota and metabolism. Frontiers Media S.A. 2023-02-06 /pmc/articles/PMC9939636/ /pubmed/36814509 http://dx.doi.org/10.3389/fnut.2023.1080825 Text en Copyright © 2023 Chen, Chen, Wang, Cai, Liu, Zhou, Jia, Gong, Liu and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Chen, Mengyin Chen, Xuefeng Wang, Ketang Cai, Luyang Liu, Nannan Zhou, Duan Jia, Wei Gong, Pin Liu, Ning Sun, Yujiao Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice |
title | Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice |
title_full | Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice |
title_fullStr | Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice |
title_full_unstemmed | Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice |
title_short | Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice |
title_sort | effects of kiwi fruit (actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939636/ https://www.ncbi.nlm.nih.gov/pubmed/36814509 http://dx.doi.org/10.3389/fnut.2023.1080825 |
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