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Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study

PURPOSE: Vitamin D, an essential nutrient and a pleiotropic steroid hormone, has been reported to be associated with the risk and severity in patients infected with Coronavirus Disease-2019 (COVID-19). The role of vitamin D in predicting clinical outcome for COVID-19 patients is unknown. Here, we ai...

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Autores principales: Chen, Changqiang, Li, Pu, Chen, Jiuming, Liu, Chunxiao, Wang, Xiaodan, Cai, Jialin, Xiang, Enfei, Gu, Zhidong, Chen, Peizhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939667/
https://www.ncbi.nlm.nih.gov/pubmed/36814826
http://dx.doi.org/10.2147/IDR.S400561
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author Chen, Changqiang
Li, Pu
Chen, Jiuming
Liu, Chunxiao
Wang, Xiaodan
Cai, Jialin
Xiang, Enfei
Gu, Zhidong
Chen, Peizhan
author_facet Chen, Changqiang
Li, Pu
Chen, Jiuming
Liu, Chunxiao
Wang, Xiaodan
Cai, Jialin
Xiang, Enfei
Gu, Zhidong
Chen, Peizhan
author_sort Chen, Changqiang
collection PubMed
description PURPOSE: Vitamin D, an essential nutrient and a pleiotropic steroid hormone, has been reported to be associated with the risk and severity in patients infected with Coronavirus Disease-2019 (COVID-19). The role of vitamin D in predicting clinical outcome for COVID-19 patients is unknown. Here, we aimed to determine the prognostic value of plasma 25(OH)D level in COVID-19 patients. PATIENTS AND METHODS: A total of 158 patients infected with novel COVID-19 Omicron variants in Shanghai were recruited in this study and were categorized into three groups by the tertile levels of plasma 25(OH)D. Plasma 25(OH)D level was determined along with routine blood tests related to liver and renal functions in newly diagnosed COVID-19 patients at admission. The nucleic acid negative conversion time of throat swab samples was evaluated as the primary clinical outcome. The prognostic value of clinical characteristics and plasma 25(OH)D level was assessed using the Kaplan–Meier plot and Cox proportional hazards regression tests. RESULTS: Higher level of plasma 25(OH)D level in COVID-19 patients was independently associated with shorter nucleic acid negative conversion time from COVID-19 infection (multivariate adjusted HR: 0.54, 95%CI: 0.35–0.82, P=0.004, tertile 2 vs 1; multivariate adjusted HR: 0.60, 95%CI: 0.39–0.90, P=0.014, tertile 3 vs 1). CONCLUSION: Plasma 25(OH)D level may serve as an independent prognostic factor in COVID-19 patient. Our findings indicate the protective roles of vitamin D supplementation in the regiment of patients with COVID-19.
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spelling pubmed-99396672023-02-21 Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study Chen, Changqiang Li, Pu Chen, Jiuming Liu, Chunxiao Wang, Xiaodan Cai, Jialin Xiang, Enfei Gu, Zhidong Chen, Peizhan Infect Drug Resist Original Research PURPOSE: Vitamin D, an essential nutrient and a pleiotropic steroid hormone, has been reported to be associated with the risk and severity in patients infected with Coronavirus Disease-2019 (COVID-19). The role of vitamin D in predicting clinical outcome for COVID-19 patients is unknown. Here, we aimed to determine the prognostic value of plasma 25(OH)D level in COVID-19 patients. PATIENTS AND METHODS: A total of 158 patients infected with novel COVID-19 Omicron variants in Shanghai were recruited in this study and were categorized into three groups by the tertile levels of plasma 25(OH)D. Plasma 25(OH)D level was determined along with routine blood tests related to liver and renal functions in newly diagnosed COVID-19 patients at admission. The nucleic acid negative conversion time of throat swab samples was evaluated as the primary clinical outcome. The prognostic value of clinical characteristics and plasma 25(OH)D level was assessed using the Kaplan–Meier plot and Cox proportional hazards regression tests. RESULTS: Higher level of plasma 25(OH)D level in COVID-19 patients was independently associated with shorter nucleic acid negative conversion time from COVID-19 infection (multivariate adjusted HR: 0.54, 95%CI: 0.35–0.82, P=0.004, tertile 2 vs 1; multivariate adjusted HR: 0.60, 95%CI: 0.39–0.90, P=0.014, tertile 3 vs 1). CONCLUSION: Plasma 25(OH)D level may serve as an independent prognostic factor in COVID-19 patient. Our findings indicate the protective roles of vitamin D supplementation in the regiment of patients with COVID-19. Dove 2023-02-15 /pmc/articles/PMC9939667/ /pubmed/36814826 http://dx.doi.org/10.2147/IDR.S400561 Text en © 2023 Chen et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Chen, Changqiang
Li, Pu
Chen, Jiuming
Liu, Chunxiao
Wang, Xiaodan
Cai, Jialin
Xiang, Enfei
Gu, Zhidong
Chen, Peizhan
Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
title Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
title_full Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
title_fullStr Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
title_full_unstemmed Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
title_short Plasma 25(OH)D Level is Associated with the Nucleic Acid Negative Conversion Time of COVID-19 Patients: An Exploratory Study
title_sort plasma 25(oh)d level is associated with the nucleic acid negative conversion time of covid-19 patients: an exploratory study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939667/
https://www.ncbi.nlm.nih.gov/pubmed/36814826
http://dx.doi.org/10.2147/IDR.S400561
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