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Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise

Introduction: As the number of COVID-19 cases begin to diminish it is important to turn our attention to any long-term issues that may be associated with a prior infection. Cardiovascular defects have been noted following prior SARS-CoV-2 infections. However, less is known about how a previous infec...

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Autores principales: Chan, Jillian, Senior, Hailey, Homitz, Jessica, Cashin, Niamh, Guers, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939691/
https://www.ncbi.nlm.nih.gov/pubmed/36814473
http://dx.doi.org/10.3389/fphys.2023.1052369
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author Chan, Jillian
Senior, Hailey
Homitz, Jessica
Cashin, Niamh
Guers, John J.
author_facet Chan, Jillian
Senior, Hailey
Homitz, Jessica
Cashin, Niamh
Guers, John J.
author_sort Chan, Jillian
collection PubMed
description Introduction: As the number of COVID-19 cases begin to diminish it is important to turn our attention to any long-term issues that may be associated with a prior infection. Cardiovascular defects have been noted following prior SARS-CoV-2 infections. However, less is known about how a previous infection alters the cardiovascular response to exercise. Further, differences may exist during exercise between previously SARS-CoV-2 positive individuals who had symptoms (symptomatic) relative to those who did not have symptoms (asymptomatic). We hypothesized that previously symptomatic (S) COVID-19 recoveries have an altered cardiovascular response to acute exercise relative to both control (CON; never infected), and previously COVID-19 positive asymptomatic (AS) individuals. Methods: Twenty-seven subjects (CON = 9; AS = 9; S = 9) underwent 30 min of submaximal treadmill exercise. During exercise, blood pressure was recorded on the brachial artery every 5 min and 3-lead electrocardiography was measured continuously. Indirect indicators of autonomic nervous system health: heart rate variability and blood pressure variability were measured during each session. Baseline mean arterial pressure (MAP) was taken prior to exercise in seated, standing and supine positions. Results: Blood pressure was similar (p > 0.05) amongst all three groups. There were no differences between average heart rate (HR; CON = 104 ± 4 BPM vs AS = 118 ± 6 BPM vs. S = 112 ± 3 BPM), mean arterial pressure (MAP; CON = 108 ± 4 mmHg vs. AS = 105 ± 13 mmHg vs. S = 108 ± 7 mmHg) or oxygen consumption (VO(2)) between groups during a bout of exercise. However, the standard deviation of the inter beat intervals of normal sinus beats, a measure of heart rate variability (HRV) (CON = 138 ± 2.8 m vs. AS = 156 ± 6 m vs. S = 77.7 ± 11 m; p < 0.05) and blood pressure variability (BPV; CON = 5.18 ± 1.1 vs. AS = 12.1 ± 0.88 mmHg vs. S = 10.2 ± 10.7 mmHg; p < 0.05) were different in our S group. Further, when HRV was assessed in the frequency domain the very low frequency was different during exercise in the S group relative to the other groups. Discussion: Collectively, these data suggest that a previous symptomatic SARS-CoV-2 infection may alter heart rate and blood pressure regulation during exercise.
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spelling pubmed-99396912023-02-21 Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise Chan, Jillian Senior, Hailey Homitz, Jessica Cashin, Niamh Guers, John J. Front Physiol Physiology Introduction: As the number of COVID-19 cases begin to diminish it is important to turn our attention to any long-term issues that may be associated with a prior infection. Cardiovascular defects have been noted following prior SARS-CoV-2 infections. However, less is known about how a previous infection alters the cardiovascular response to exercise. Further, differences may exist during exercise between previously SARS-CoV-2 positive individuals who had symptoms (symptomatic) relative to those who did not have symptoms (asymptomatic). We hypothesized that previously symptomatic (S) COVID-19 recoveries have an altered cardiovascular response to acute exercise relative to both control (CON; never infected), and previously COVID-19 positive asymptomatic (AS) individuals. Methods: Twenty-seven subjects (CON = 9; AS = 9; S = 9) underwent 30 min of submaximal treadmill exercise. During exercise, blood pressure was recorded on the brachial artery every 5 min and 3-lead electrocardiography was measured continuously. Indirect indicators of autonomic nervous system health: heart rate variability and blood pressure variability were measured during each session. Baseline mean arterial pressure (MAP) was taken prior to exercise in seated, standing and supine positions. Results: Blood pressure was similar (p > 0.05) amongst all three groups. There were no differences between average heart rate (HR; CON = 104 ± 4 BPM vs AS = 118 ± 6 BPM vs. S = 112 ± 3 BPM), mean arterial pressure (MAP; CON = 108 ± 4 mmHg vs. AS = 105 ± 13 mmHg vs. S = 108 ± 7 mmHg) or oxygen consumption (VO(2)) between groups during a bout of exercise. However, the standard deviation of the inter beat intervals of normal sinus beats, a measure of heart rate variability (HRV) (CON = 138 ± 2.8 m vs. AS = 156 ± 6 m vs. S = 77.7 ± 11 m; p < 0.05) and blood pressure variability (BPV; CON = 5.18 ± 1.1 vs. AS = 12.1 ± 0.88 mmHg vs. S = 10.2 ± 10.7 mmHg; p < 0.05) were different in our S group. Further, when HRV was assessed in the frequency domain the very low frequency was different during exercise in the S group relative to the other groups. Discussion: Collectively, these data suggest that a previous symptomatic SARS-CoV-2 infection may alter heart rate and blood pressure regulation during exercise. Frontiers Media S.A. 2023-02-06 /pmc/articles/PMC9939691/ /pubmed/36814473 http://dx.doi.org/10.3389/fphys.2023.1052369 Text en Copyright © 2023 Chan, Senior, Homitz, Cashin and Guers. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Chan, Jillian
Senior, Hailey
Homitz, Jessica
Cashin, Niamh
Guers, John J.
Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise
title Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise
title_full Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise
title_fullStr Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise
title_full_unstemmed Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise
title_short Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise
title_sort individuals with a previous symptomatic covid-19 infection have altered heart rate and blood pressure variability during acute exercise
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939691/
https://www.ncbi.nlm.nih.gov/pubmed/36814473
http://dx.doi.org/10.3389/fphys.2023.1052369
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