Cargando…

Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration

Enzymes of the mixed lineage leukemia (MLL) family of histone H3 lysine 4 (H3K4) methyltransferases are critical for cellular differentiation and development and are regulated by interaction with a conserved subcomplex consisting of WDR5, RbBP5, Ash2L, and DPY30. While pairwise interactions between...

Descripción completa

Detalles Bibliográficos
Autores principales:	Namitz, Kevin E.W., Tan, Song, Cosgrove, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939731/ https://www.ncbi.nlm.nih.gov/pubmed/36623730 http://dx.doi.org/10.1016/j.jbc.2023.102874

Ejemplares similares

Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation
por: Namitz, Kevin E.W., et al.
Publicado: (2023)

Probing multiple enzymatic methylation events in real time with NMR spectroscopy
por: Usher, Emery T., et al.
Publicado: (2021)

Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes
por: Zheng, Yongxin, et al.
Publicado: (2021)

Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome
por: Rahman, Sanim, et al.
Publicado: (2022)

Automethylation Activities within the Mixed Lineage Leukemia-1 (MLL1) Core Complex Reveal Evidence Supporting a “Two-active Site” Model for Multiple Histone H3 Lysine 4 Methylation
por: Patel, Anamika, et al.
Publicado: (2014)

MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres
por: Malik, Kausika Kumar, et al.
Publicado: (2023)

Advances in direct detection of lysine methylation and acetylation by nuclear magnetic resonance using (13)C-enriched cofactors
por: Fraser, Olivia A., et al.
Publicado: (2023)

Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers
por: Sun, Jian, et al.
Publicado: (2016)

Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly
por: Karchin, Joshua M., et al.
Publicado: (2017)

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development
por: Jang, Younghoon, et al.
Publicado: (2019)

Crosstalk between NSL Histone Acetyltransferase and MLL/SET Complexes: NSL Complex Functions in Promoting Histone H3K4 Di-Methylation Activity by MLL/SET Complexes
por: Zhao, Xiaoming, et al.
Publicado: (2013)

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
por: Zhang, Yi, et al.
Publicado: (2019)

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4
por: Liu, Yanli, et al.
Publicado: (2019)

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
por: Jain, Kanishk, et al.
Publicado: (2023)

The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex
por: Karakkat, Jimsheena V, et al.
Publicado: (2019)

The Minimal k-Core Problem for Modeling k-Assemblies
por: Wood, Cynthia I., et al.
Publicado: (2015)

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation
por: Boileau, Ryan M., et al.
Publicado: (2023)

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape
por: Wang, Lan-Hsin, et al.
Publicado: (2021)

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome
por: Park, Sang Ho, et al.
Publicado: (2019)

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199
por: Benito, Juliana M., et al.
Publicado: (2015)

Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)
por: Sun, Q-Y, et al.
Publicado: (2017)

SET1/MLL family of proteins: functions beyond histone methylation
por: Sugeedha, Jeyapal, et al.
Publicado: (2020)

NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
por: Aguilar-Arnal, Lorena, et al.
Publicado: (2015)

Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation
por: Zhang, Hongmei, et al.
Publicado: (2014)

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3
por: Jozwik, Kamila M., et al.
Publicado: (2016)

Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer
por: Lin, Xiang, et al.
Publicado: (2023)

Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment
por: Zhou, Cefan, et al.
Publicado: (2016)

Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice
por: Goldsworthy, Michelle, et al.
Publicado: (2013)

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
por: Lee, Ji-Eun, et al.
Publicado: (2013)

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts
por: Liu, Liu, et al.
Publicado: (2016)

Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia
por: Richter, William F, et al.
Publicado: (2021)

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95
por: Jiang, Hao, et al.
Publicado: (2013)

Publisher Correction: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome
por: Park, Sang Ho, et al.
Publicado: (2020)

The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex
por: Han, Jianming, et al.
Publicado: (2019)

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation
por: Ropa, James, et al.
Publicado: (2019)

Essential Functions of MLL1 and MLL2 in Retinal Development and Cone Cell Maintenance
por: Sun, Chi, et al.
Publicado: (2022)

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation
por: Godfrey, Laura, et al.
Publicado: (2017)

PTIP-Associated Protein 1: More Than a Component of the MLL3/4 Complex
por: Liu, Bo, et al.
Publicado: (2022)

Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors
por: Yang, Zhenhua, et al.
Publicado: (2015)

Replication stress in MLL-rearrangements
por: Milyavsky, Michael, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qd20rnedfsh2j1v4n6ot05oje3