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Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration

Enzymes of the mixed lineage leukemia (MLL) family of histone H3 lysine 4 (H3K4) methyltransferases are critical for cellular differentiation and development and are regulated by interaction with a conserved subcomplex consisting of WDR5, RbBP5, Ash2L, and DPY30. While pairwise interactions between...

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Detalles Bibliográficos
Autores principales:	Namitz, Kevin E.W., Tan, Song, Cosgrove, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939731/ https://www.ncbi.nlm.nih.gov/pubmed/36623730 http://dx.doi.org/10.1016/j.jbc.2023.102874

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