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Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide

Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing a partial deficit of beta cells and islet amyloid derived from islet amyloid polypeptide (IAPP). IAPP is...

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Detalles Bibliográficos
Autores principales:	Gurlo, Tatyana, Prakash, Thazha P., Wang, Zhongying, Archang, Maani, Pei, Lina, Rosenberger, Madeline, Pirie, Elaine, Lee, Richard G., Butler, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939749/ https://www.ncbi.nlm.nih.gov/pubmed/36814640 http://dx.doi.org/10.3389/fmolb.2023.1096286

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