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A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata

Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioural stress in vertebrate and urochordate models, yet despite numerous studies in higher animals, there is limited knowledge of its rol...

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Autores principales: Abramov, Tomer, Suwansa-ard, Saowaros, da Silva, Patricia Mirella, Wang, Tianfang, Dove, Michael, O’Connor, Wayne, Parker, Laura, Russell, Fraser D., Lovejoy, David A., Cummins, Scott F., Elizur, Abigail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939839/
https://www.ncbi.nlm.nih.gov/pubmed/36814576
http://dx.doi.org/10.3389/fendo.2023.1020368
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author Abramov, Tomer
Suwansa-ard, Saowaros
da Silva, Patricia Mirella
Wang, Tianfang
Dove, Michael
O’Connor, Wayne
Parker, Laura
Russell, Fraser D.
Lovejoy, David A.
Cummins, Scott F.
Elizur, Abigail
author_facet Abramov, Tomer
Suwansa-ard, Saowaros
da Silva, Patricia Mirella
Wang, Tianfang
Dove, Michael
O’Connor, Wayne
Parker, Laura
Russell, Fraser D.
Lovejoy, David A.
Cummins, Scott F.
Elizur, Abigail
author_sort Abramov, Tomer
collection PubMed
description Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioural stress in vertebrate and urochordate models, yet despite numerous studies in higher animals, there is limited knowledge of its role in invertebrates. In particular, there are no studies on TCAP’s effects on the heart of any metazoan, which is a critical organ in the stress response. We used the Sydney rock oyster (SRO) as an invertebrate model to investigate a potential role for sroTCAP in regulating cardiac activity, including during stress. sroTCAP is localized to the neural innervation network of the SRO heart, and suggested binding with various heart proteins related to metabolism and stress, including SOD, GAPDH and metabotropic glutamate receptor. Intramuscular injection of sroTCAP (10 pmol) significantly altered the expression of heart genes that are known to regulate remodelling processes under different conditions, and modulated several gene families responsible for stress mitigation. sroTCAP (1 and 10 pmol) was shown to cause transient bradycardia (heart rate was reduced by up to 63% and for up to 40 min post-administration), indicative of an unstressed state. In summary, this study has established a role for a TCAP in the regulation of cardiac activity through modulation of physiological and molecular components associated with energy conservation, stress and adaptation. This represents a novel function for TCAP and may have implications for higher-order metazoans.
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spelling pubmed-99398392023-02-21 A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata Abramov, Tomer Suwansa-ard, Saowaros da Silva, Patricia Mirella Wang, Tianfang Dove, Michael O’Connor, Wayne Parker, Laura Russell, Fraser D. Lovejoy, David A. Cummins, Scott F. Elizur, Abigail Front Endocrinol (Lausanne) Endocrinology Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioural stress in vertebrate and urochordate models, yet despite numerous studies in higher animals, there is limited knowledge of its role in invertebrates. In particular, there are no studies on TCAP’s effects on the heart of any metazoan, which is a critical organ in the stress response. We used the Sydney rock oyster (SRO) as an invertebrate model to investigate a potential role for sroTCAP in regulating cardiac activity, including during stress. sroTCAP is localized to the neural innervation network of the SRO heart, and suggested binding with various heart proteins related to metabolism and stress, including SOD, GAPDH and metabotropic glutamate receptor. Intramuscular injection of sroTCAP (10 pmol) significantly altered the expression of heart genes that are known to regulate remodelling processes under different conditions, and modulated several gene families responsible for stress mitigation. sroTCAP (1 and 10 pmol) was shown to cause transient bradycardia (heart rate was reduced by up to 63% and for up to 40 min post-administration), indicative of an unstressed state. In summary, this study has established a role for a TCAP in the regulation of cardiac activity through modulation of physiological and molecular components associated with energy conservation, stress and adaptation. This represents a novel function for TCAP and may have implications for higher-order metazoans. Frontiers Media S.A. 2023-02-06 /pmc/articles/PMC9939839/ /pubmed/36814576 http://dx.doi.org/10.3389/fendo.2023.1020368 Text en Copyright © 2023 Abramov, Suwansa-ard, da Silva, Wang, Dove, O’Connor, Parker, Russell, Lovejoy, Cummins and Elizur https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Abramov, Tomer
Suwansa-ard, Saowaros
da Silva, Patricia Mirella
Wang, Tianfang
Dove, Michael
O’Connor, Wayne
Parker, Laura
Russell, Fraser D.
Lovejoy, David A.
Cummins, Scott F.
Elizur, Abigail
A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
title A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
title_full A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
title_fullStr A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
title_full_unstemmed A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
title_short A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
title_sort novel role for teneurin c-terminal associated peptide (tcap) in the regulation of cardiac activity in the sydney rock oyster, saccostrea glomerata
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939839/
https://www.ncbi.nlm.nih.gov/pubmed/36814576
http://dx.doi.org/10.3389/fendo.2023.1020368
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