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A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics

Multiple myeloma is a hematologic malignancy and a subtype of plasma cell dyscrasias, which accounts for 13% of all hematologic malignancies. It mainly affects older adults and is diagnosed in only 2% of the young population under the age of 40 years. This report presents a 33-year-old man diagnosed...

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Autores principales: Iranijam, Effat, Matin, Somaieh, Negaresh, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940169/
https://www.ncbi.nlm.nih.gov/pubmed/36814752
http://dx.doi.org/10.1177/11795476231157245
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author Iranijam, Effat
Matin, Somaieh
Negaresh, Mohammad
author_facet Iranijam, Effat
Matin, Somaieh
Negaresh, Mohammad
author_sort Iranijam, Effat
collection PubMed
description Multiple myeloma is a hematologic malignancy and a subtype of plasma cell dyscrasias, which accounts for 13% of all hematologic malignancies. It mainly affects older adults and is diagnosed in only 2% of the young population under the age of 40 years. This report presents a 33-year-old man diagnosed with Multiple myeloma with 4 poor prognostic specifications consisting of amplification of the 1q21, Translocation of t(4;14), deletion of the 6q21 and 13q14, along with decreased chromosome count to 44, X,-Y. Even though the combination of 4 poor prognostic cytogenetics in young patients is rare, he responded significantly to the Bortezomib regimen. He was selected as a candidate for bone marrow transplantation. The treatments get interrupted 2 days after the first session of the fifth cycle due to an undesirable COVID-19 infection. After 20 days, the symptoms return, and paraclinical findings show signs of MM relapse.
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spelling pubmed-99401692023-02-21 A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics Iranijam, Effat Matin, Somaieh Negaresh, Mohammad Clin Med Insights Case Rep Case Report Multiple myeloma is a hematologic malignancy and a subtype of plasma cell dyscrasias, which accounts for 13% of all hematologic malignancies. It mainly affects older adults and is diagnosed in only 2% of the young population under the age of 40 years. This report presents a 33-year-old man diagnosed with Multiple myeloma with 4 poor prognostic specifications consisting of amplification of the 1q21, Translocation of t(4;14), deletion of the 6q21 and 13q14, along with decreased chromosome count to 44, X,-Y. Even though the combination of 4 poor prognostic cytogenetics in young patients is rare, he responded significantly to the Bortezomib regimen. He was selected as a candidate for bone marrow transplantation. The treatments get interrupted 2 days after the first session of the fifth cycle due to an undesirable COVID-19 infection. After 20 days, the symptoms return, and paraclinical findings show signs of MM relapse. SAGE Publications 2023-02-18 /pmc/articles/PMC9940169/ /pubmed/36814752 http://dx.doi.org/10.1177/11795476231157245 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Iranijam, Effat
Matin, Somaieh
Negaresh, Mohammad
A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics
title A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics
title_full A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics
title_fullStr A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics
title_full_unstemmed A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics
title_short A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics
title_sort case of a young multiple myeloma patient with poor prognostic cytogenetics
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940169/
https://www.ncbi.nlm.nih.gov/pubmed/36814752
http://dx.doi.org/10.1177/11795476231157245
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