A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating K(v)1.1

BACKGROUND: Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that functional LGI1 is secreted by excitatory neurons, GABAergic interneurons, and astrocytes, and regulates AMPA-type glut...

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Detalles Bibliográficos
Autores principales: Zhou, Lin, Wang, Kang, Xu, Yuxiang, Dong, Bin-Bin, Wu, Deng-Chang, Wang, Zhao-Xiang, Wang, Xin-Tai, Cai, Xin-Yu, Yang, Jin-Tao, Zheng, Rui, Chen, Wei, Shen, Ying, Wei, Jian-She
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940402/
https://www.ncbi.nlm.nih.gov/pubmed/36804022
http://dx.doi.org/10.1186/s13578-023-00983-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940402/
https://www.ncbi.nlm.nih.gov/pubmed/36804022
http://dx.doi.org/10.1186/s13578-023-00983-y

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