MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including can...

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Autores principales: Faramin Lashkarian, Mahboobeh, Hashemipour, Nasrin, Niaraki, Negin, Soghala, Shahrad, Moradi, Ali, Sarhangi, Sareh, Hatami, Mahsa, Aghaei-Zarch, Fatemehsadat, Khosravifar, Mina, Mohammadzadeh, Alireza, Najafi, Sajad, Majidpoor, Jamal, Farnia, Poopak, Aghaei-Zarch, Seyed Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940444/
https://www.ncbi.nlm.nih.gov/pubmed/36803831
http://dx.doi.org/10.1186/s12935-023-02868-z
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author Faramin Lashkarian, Mahboobeh
Hashemipour, Nasrin
Niaraki, Negin
Soghala, Shahrad
Moradi, Ali
Sarhangi, Sareh
Hatami, Mahsa
Aghaei-Zarch, Fatemehsadat
Khosravifar, Mina
Mohammadzadeh, Alireza
Najafi, Sajad
Majidpoor, Jamal
Farnia, Poopak
Aghaei-Zarch, Seyed Mohsen
author_facet Faramin Lashkarian, Mahboobeh
Hashemipour, Nasrin
Niaraki, Negin
Soghala, Shahrad
Moradi, Ali
Sarhangi, Sareh
Hatami, Mahsa
Aghaei-Zarch, Fatemehsadat
Khosravifar, Mina
Mohammadzadeh, Alireza
Najafi, Sajad
Majidpoor, Jamal
Farnia, Poopak
Aghaei-Zarch, Seyed Mohsen
author_sort Faramin Lashkarian, Mahboobeh
collection PubMed
description MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.
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spelling pubmed-99404442023-02-21 MicroRNA-122 in human cancers: from mechanistic to clinical perspectives Faramin Lashkarian, Mahboobeh Hashemipour, Nasrin Niaraki, Negin Soghala, Shahrad Moradi, Ali Sarhangi, Sareh Hatami, Mahsa Aghaei-Zarch, Fatemehsadat Khosravifar, Mina Mohammadzadeh, Alireza Najafi, Sajad Majidpoor, Jamal Farnia, Poopak Aghaei-Zarch, Seyed Mohsen Cancer Cell Int Review MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy. BioMed Central 2023-02-20 /pmc/articles/PMC9940444/ /pubmed/36803831 http://dx.doi.org/10.1186/s12935-023-02868-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Faramin Lashkarian, Mahboobeh
Hashemipour, Nasrin
Niaraki, Negin
Soghala, Shahrad
Moradi, Ali
Sarhangi, Sareh
Hatami, Mahsa
Aghaei-Zarch, Fatemehsadat
Khosravifar, Mina
Mohammadzadeh, Alireza
Najafi, Sajad
Majidpoor, Jamal
Farnia, Poopak
Aghaei-Zarch, Seyed Mohsen
MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
title MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
title_full MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
title_fullStr MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
title_full_unstemmed MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
title_short MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
title_sort microrna-122 in human cancers: from mechanistic to clinical perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940444/
https://www.ncbi.nlm.nih.gov/pubmed/36803831
http://dx.doi.org/10.1186/s12935-023-02868-z
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