Spirocitrinols A and B, citrinin derivatives with a spiro[chromane-2,3′-isochromane] skeleton from Penicillium citrinum

Spirocitrinols A (1) and B (2), two new citrinin-derived metabolites possessing a spiro[chromane-2,3′-isochromane] skeleton, were isolated from cultures of Penicillium citrinum. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were assigned by ele...

Descripción completa

Detalles Bibliográficos
Autores principales: Tong, Junjie, Zhang, Yang, Xu, Yang, Han, Yangyang, Li, Chuan, Zhuang, Wenying, Che, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940459/
https://www.ncbi.nlm.nih.gov/pubmed/36814878
http://dx.doi.org/10.1039/d3ra00665d
Descripción
Sumario:Spirocitrinols A (1) and B (2), two new citrinin-derived metabolites possessing a spiro[chromane-2,3′-isochromane] skeleton, were isolated from cultures of Penicillium citrinum. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were assigned by electronic circular dichroism calculations. Compound 2 is the first naturally occurring trimeric citrinin derivative with a spiro[chromane-2,3′-isochromane] core. Compound 1 showed modest cytotoxicity against A549 human tumor cells.

Ejemplares similares