Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity

Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in hu...

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Detalles Bibliográficos
Autores principales: Yoshiji, Satoshi, Butler-Laporte, Guillaume, Lu, Tianyuan, Willett, Julian Daniel Sunday, Su, Chen-Yang, Nakanishi, Tomoko, Morrison, David R., Chen, Yiheng, Liang, Kevin, Hultström, Michael, Ilboudo, Yann, Afrasiabi, Zaman, Lan, Shanshan, Duggan, Naomi, DeLuca, Chantal, Vaezi, Mitra, Tselios, Chris, Xue, Xiaoqing, Bouab, Meriem, Shi, Fangyi, Laurent, Laetitia, Münter, Hans Markus, Afilalo, Marc, Afilalo, Jonathan, Mooser, Vincent, Timpson, Nicholas J., Zeberg, Hugo, Zhou, Sirui, Forgetta, Vincenzo, Farjoun, Yossi, Richards, J. Brent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940690/
https://www.ncbi.nlm.nih.gov/pubmed/36805566
http://dx.doi.org/10.1038/s42255-023-00742-w

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