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Associations of smoking with early- and late-onset colorectal cancer
BACKGROUND: Incidence of colorectal cancer (CRC) in younger adults is increasing in many countries. Smoking is an established risk factor of CRC risk, but evidence on its impact on early-onset CRC (EOCRC) risk is limited. We aimed to evaluate the association of smoking exposure with EOCRC and compar...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940696/ https://www.ncbi.nlm.nih.gov/pubmed/36759940 http://dx.doi.org/10.1093/jncics/pkad004 |
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author | Li, Hengjing Chen, Xuechen Hoffmeister, Michael Brenner, Hermann |
author_facet | Li, Hengjing Chen, Xuechen Hoffmeister, Michael Brenner, Hermann |
author_sort | Li, Hengjing |
collection | PubMed |
description | BACKGROUND: Incidence of colorectal cancer (CRC) in younger adults is increasing in many countries. Smoking is an established risk factor of CRC risk, but evidence on its impact on early-onset CRC (EOCRC) risk is limited. We aimed to evaluate the association of smoking exposure with EOCRC and compare it with late-onset CRC (LOCRC). METHODS: Smoking history and other known or suspected CRC risk factors were ascertained in detail in personal interviews among 6264 CRC patients and 6866 controls (frequency matched for age, sex, and county of residence) who were recruited in 2003-2020 in the DACHS study (Darmkrebs: Chancen der Verhütung durch Screening [German]; Colorectal Cancer: Chances for Prevention Through Screening [English]), a population-based case-control study from Germany. Associations of smoking with EOCRC (<55 years, 724 cases, 787 controls) and LOCRC (≥55years, 5540 cases, 6079 controls) were estimated using multiple logistic regression. RESULTS: Smoking exposure was much higher among EOCRC cases than among controls, and strong associations of smoking were observed for both EOCRC and LOCR. Adjusted odds ratios for EOCRC and LOCRC were as follows: current smoking: 1.57 (95% confidence interval [CI] = 1.20 to 2.04, P < .001) and 1.46 (95% CI = 1.28 to 1.67, P < .001); former smoking: 1.39 (95% CI = 1.07 to 1.81, P = .01) and 1.24 (95% CI = 1.13 to 1.36, P < .001); per 10 pack-years: 1.15 (95% CI = 1.05 to 1.27, P < .001) and 1.05 (95% CI = 1.03 to 1.08, P < .001). These patterns were similar for colon and rectum cancer and for early- and late-stage CRC. CONCLUSION: Smoking is a strong risk factor for both EOCRC and LOCRC. |
format | Online Article Text |
id | pubmed-9940696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99406962023-02-21 Associations of smoking with early- and late-onset colorectal cancer Li, Hengjing Chen, Xuechen Hoffmeister, Michael Brenner, Hermann JNCI Cancer Spectr Article BACKGROUND: Incidence of colorectal cancer (CRC) in younger adults is increasing in many countries. Smoking is an established risk factor of CRC risk, but evidence on its impact on early-onset CRC (EOCRC) risk is limited. We aimed to evaluate the association of smoking exposure with EOCRC and compare it with late-onset CRC (LOCRC). METHODS: Smoking history and other known or suspected CRC risk factors were ascertained in detail in personal interviews among 6264 CRC patients and 6866 controls (frequency matched for age, sex, and county of residence) who were recruited in 2003-2020 in the DACHS study (Darmkrebs: Chancen der Verhütung durch Screening [German]; Colorectal Cancer: Chances for Prevention Through Screening [English]), a population-based case-control study from Germany. Associations of smoking with EOCRC (<55 years, 724 cases, 787 controls) and LOCRC (≥55years, 5540 cases, 6079 controls) were estimated using multiple logistic regression. RESULTS: Smoking exposure was much higher among EOCRC cases than among controls, and strong associations of smoking were observed for both EOCRC and LOCR. Adjusted odds ratios for EOCRC and LOCRC were as follows: current smoking: 1.57 (95% confidence interval [CI] = 1.20 to 2.04, P < .001) and 1.46 (95% CI = 1.28 to 1.67, P < .001); former smoking: 1.39 (95% CI = 1.07 to 1.81, P = .01) and 1.24 (95% CI = 1.13 to 1.36, P < .001); per 10 pack-years: 1.15 (95% CI = 1.05 to 1.27, P < .001) and 1.05 (95% CI = 1.03 to 1.08, P < .001). These patterns were similar for colon and rectum cancer and for early- and late-stage CRC. CONCLUSION: Smoking is a strong risk factor for both EOCRC and LOCRC. Oxford University Press 2023-02-09 /pmc/articles/PMC9940696/ /pubmed/36759940 http://dx.doi.org/10.1093/jncics/pkad004 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Article Li, Hengjing Chen, Xuechen Hoffmeister, Michael Brenner, Hermann Associations of smoking with early- and late-onset colorectal cancer |
title | Associations of smoking with early- and late-onset colorectal cancer |
title_full | Associations of smoking with early- and late-onset colorectal cancer |
title_fullStr | Associations of smoking with early- and late-onset colorectal cancer |
title_full_unstemmed | Associations of smoking with early- and late-onset colorectal cancer |
title_short | Associations of smoking with early- and late-onset colorectal cancer |
title_sort | associations of smoking with early- and late-onset colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940696/ https://www.ncbi.nlm.nih.gov/pubmed/36759940 http://dx.doi.org/10.1093/jncics/pkad004 |
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