Cargando…
A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa
Adenovirus type 7 (HAdV7) is one of the most pathogenic human adenoviruses (HAdVs) and can cause severe illness and even death, particularly in people with weakened immune systems. Many countries worldwide have experienced epidemics of this highly contagious pathogen, including China and Sierra Leon...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940762/ https://www.ncbi.nlm.nih.gov/pubmed/36815162 http://dx.doi.org/10.3389/fpubh.2023.1095343 |
_version_ | 1784891148513312768 |
---|---|
author | Wang, Busen Li, Jianhua Wu, Shipo Wang, Yudong Chen, Yi Zhai, Yanfang Song, Xiaohong Zhao, Zhenghao Zhang, Zhe Zhang, Jinlong Yu, Rui Hou, Lihua Chen, Wei |
author_facet | Wang, Busen Li, Jianhua Wu, Shipo Wang, Yudong Chen, Yi Zhai, Yanfang Song, Xiaohong Zhao, Zhenghao Zhang, Zhe Zhang, Jinlong Yu, Rui Hou, Lihua Chen, Wei |
author_sort | Wang, Busen |
collection | PubMed |
description | Adenovirus type 7 (HAdV7) is one of the most pathogenic human adenoviruses (HAdVs) and can cause severe illness and even death, particularly in people with weakened immune systems. Many countries worldwide have experienced epidemics of this highly contagious pathogen, including China and Sierra Leone; however, studies describing the seroprevalence of anti-HAdV7 neutralizing antibodies (nAbs) are still lacking. Herein, we established an efficient neutralization assay based on a recombinant luciferase-expressing HAdV7 virus (HAd7-Luc) to monitor historical HAdV7 infections and predict outbreak distributions. Among the 2,350 serum samples collected from eight sites in China and Sierra Leone in this cross-sectional serological survey, the overall proportion of anti-HAdV7-seropositive individuals was nearly 60%, with higher seroprevalence rates in Sierra Leone than in China. Regionally, HAdV7 nAb titers were higher in China than in Sierra Leone and showed a geographic variation across different regions. Regardless of the location, the seropositive rate of HAdV7 nAb was lower than that of HAdV5 nAb, as was the nAb titer. The prevalence rates of antibodies against HAdV7 and HAdV5 were both related to age but not to sex. In addition, serologic cross-reactions were rarely observed among people infected with HAdV7 and HAdV5. These results indicate a humoral immune response acquired through endemic HAdV7 infection and enrich the understanding of not only the epidemiological prevention and control of HAdV7 but also the clinical application of HAdV7-based vaccines or gene therapy tools. |
format | Online Article Text |
id | pubmed-9940762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99407622023-02-21 A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa Wang, Busen Li, Jianhua Wu, Shipo Wang, Yudong Chen, Yi Zhai, Yanfang Song, Xiaohong Zhao, Zhenghao Zhang, Zhe Zhang, Jinlong Yu, Rui Hou, Lihua Chen, Wei Front Public Health Public Health Adenovirus type 7 (HAdV7) is one of the most pathogenic human adenoviruses (HAdVs) and can cause severe illness and even death, particularly in people with weakened immune systems. Many countries worldwide have experienced epidemics of this highly contagious pathogen, including China and Sierra Leone; however, studies describing the seroprevalence of anti-HAdV7 neutralizing antibodies (nAbs) are still lacking. Herein, we established an efficient neutralization assay based on a recombinant luciferase-expressing HAdV7 virus (HAd7-Luc) to monitor historical HAdV7 infections and predict outbreak distributions. Among the 2,350 serum samples collected from eight sites in China and Sierra Leone in this cross-sectional serological survey, the overall proportion of anti-HAdV7-seropositive individuals was nearly 60%, with higher seroprevalence rates in Sierra Leone than in China. Regionally, HAdV7 nAb titers were higher in China than in Sierra Leone and showed a geographic variation across different regions. Regardless of the location, the seropositive rate of HAdV7 nAb was lower than that of HAdV5 nAb, as was the nAb titer. The prevalence rates of antibodies against HAdV7 and HAdV5 were both related to age but not to sex. In addition, serologic cross-reactions were rarely observed among people infected with HAdV7 and HAdV5. These results indicate a humoral immune response acquired through endemic HAdV7 infection and enrich the understanding of not only the epidemiological prevention and control of HAdV7 but also the clinical application of HAdV7-based vaccines or gene therapy tools. Frontiers Media S.A. 2023-02-06 /pmc/articles/PMC9940762/ /pubmed/36815162 http://dx.doi.org/10.3389/fpubh.2023.1095343 Text en Copyright © 2023 Wang, Li, Wu, Wang, Chen, Zhai, Song, Zhao, Zhang, Zhang, Yu, Hou and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Wang, Busen Li, Jianhua Wu, Shipo Wang, Yudong Chen, Yi Zhai, Yanfang Song, Xiaohong Zhao, Zhenghao Zhang, Zhe Zhang, Jinlong Yu, Rui Hou, Lihua Chen, Wei A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa |
title | A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa |
title_full | A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa |
title_fullStr | A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa |
title_full_unstemmed | A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa |
title_short | A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa |
title_sort | seroepidemiological survey of adenovirus type 7 circulation among healthy adults in china and in sierra leone, west africa |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940762/ https://www.ncbi.nlm.nih.gov/pubmed/36815162 http://dx.doi.org/10.3389/fpubh.2023.1095343 |
work_keys_str_mv | AT wangbusen aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT lijianhua aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT wushipo aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT wangyudong aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT chenyi aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT zhaiyanfang aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT songxiaohong aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT zhaozhenghao aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT zhangzhe aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT zhangjinlong aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT yurui aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT houlihua aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT chenwei aseroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT wangbusen seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT lijianhua seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT wushipo seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT wangyudong seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT chenyi seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT zhaiyanfang seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT songxiaohong seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT zhaozhenghao seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT zhangzhe seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT zhangjinlong seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT yurui seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT houlihua seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica AT chenwei seroepidemiologicalsurveyofadenovirustype7circulationamonghealthyadultsinchinaandinsierraleonewestafrica |