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A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa

Adenovirus type 7 (HAdV7) is one of the most pathogenic human adenoviruses (HAdVs) and can cause severe illness and even death, particularly in people with weakened immune systems. Many countries worldwide have experienced epidemics of this highly contagious pathogen, including China and Sierra Leon...

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Autores principales: Wang, Busen, Li, Jianhua, Wu, Shipo, Wang, Yudong, Chen, Yi, Zhai, Yanfang, Song, Xiaohong, Zhao, Zhenghao, Zhang, Zhe, Zhang, Jinlong, Yu, Rui, Hou, Lihua, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940762/
https://www.ncbi.nlm.nih.gov/pubmed/36815162
http://dx.doi.org/10.3389/fpubh.2023.1095343
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author Wang, Busen
Li, Jianhua
Wu, Shipo
Wang, Yudong
Chen, Yi
Zhai, Yanfang
Song, Xiaohong
Zhao, Zhenghao
Zhang, Zhe
Zhang, Jinlong
Yu, Rui
Hou, Lihua
Chen, Wei
author_facet Wang, Busen
Li, Jianhua
Wu, Shipo
Wang, Yudong
Chen, Yi
Zhai, Yanfang
Song, Xiaohong
Zhao, Zhenghao
Zhang, Zhe
Zhang, Jinlong
Yu, Rui
Hou, Lihua
Chen, Wei
author_sort Wang, Busen
collection PubMed
description Adenovirus type 7 (HAdV7) is one of the most pathogenic human adenoviruses (HAdVs) and can cause severe illness and even death, particularly in people with weakened immune systems. Many countries worldwide have experienced epidemics of this highly contagious pathogen, including China and Sierra Leone; however, studies describing the seroprevalence of anti-HAdV7 neutralizing antibodies (nAbs) are still lacking. Herein, we established an efficient neutralization assay based on a recombinant luciferase-expressing HAdV7 virus (HAd7-Luc) to monitor historical HAdV7 infections and predict outbreak distributions. Among the 2,350 serum samples collected from eight sites in China and Sierra Leone in this cross-sectional serological survey, the overall proportion of anti-HAdV7-seropositive individuals was nearly 60%, with higher seroprevalence rates in Sierra Leone than in China. Regionally, HAdV7 nAb titers were higher in China than in Sierra Leone and showed a geographic variation across different regions. Regardless of the location, the seropositive rate of HAdV7 nAb was lower than that of HAdV5 nAb, as was the nAb titer. The prevalence rates of antibodies against HAdV7 and HAdV5 were both related to age but not to sex. In addition, serologic cross-reactions were rarely observed among people infected with HAdV7 and HAdV5. These results indicate a humoral immune response acquired through endemic HAdV7 infection and enrich the understanding of not only the epidemiological prevention and control of HAdV7 but also the clinical application of HAdV7-based vaccines or gene therapy tools.
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spelling pubmed-99407622023-02-21 A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa Wang, Busen Li, Jianhua Wu, Shipo Wang, Yudong Chen, Yi Zhai, Yanfang Song, Xiaohong Zhao, Zhenghao Zhang, Zhe Zhang, Jinlong Yu, Rui Hou, Lihua Chen, Wei Front Public Health Public Health Adenovirus type 7 (HAdV7) is one of the most pathogenic human adenoviruses (HAdVs) and can cause severe illness and even death, particularly in people with weakened immune systems. Many countries worldwide have experienced epidemics of this highly contagious pathogen, including China and Sierra Leone; however, studies describing the seroprevalence of anti-HAdV7 neutralizing antibodies (nAbs) are still lacking. Herein, we established an efficient neutralization assay based on a recombinant luciferase-expressing HAdV7 virus (HAd7-Luc) to monitor historical HAdV7 infections and predict outbreak distributions. Among the 2,350 serum samples collected from eight sites in China and Sierra Leone in this cross-sectional serological survey, the overall proportion of anti-HAdV7-seropositive individuals was nearly 60%, with higher seroprevalence rates in Sierra Leone than in China. Regionally, HAdV7 nAb titers were higher in China than in Sierra Leone and showed a geographic variation across different regions. Regardless of the location, the seropositive rate of HAdV7 nAb was lower than that of HAdV5 nAb, as was the nAb titer. The prevalence rates of antibodies against HAdV7 and HAdV5 were both related to age but not to sex. In addition, serologic cross-reactions were rarely observed among people infected with HAdV7 and HAdV5. These results indicate a humoral immune response acquired through endemic HAdV7 infection and enrich the understanding of not only the epidemiological prevention and control of HAdV7 but also the clinical application of HAdV7-based vaccines or gene therapy tools. Frontiers Media S.A. 2023-02-06 /pmc/articles/PMC9940762/ /pubmed/36815162 http://dx.doi.org/10.3389/fpubh.2023.1095343 Text en Copyright © 2023 Wang, Li, Wu, Wang, Chen, Zhai, Song, Zhao, Zhang, Zhang, Yu, Hou and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Wang, Busen
Li, Jianhua
Wu, Shipo
Wang, Yudong
Chen, Yi
Zhai, Yanfang
Song, Xiaohong
Zhao, Zhenghao
Zhang, Zhe
Zhang, Jinlong
Yu, Rui
Hou, Lihua
Chen, Wei
A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa
title A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa
title_full A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa
title_fullStr A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa
title_full_unstemmed A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa
title_short A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa
title_sort seroepidemiological survey of adenovirus type 7 circulation among healthy adults in china and in sierra leone, west africa
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940762/
https://www.ncbi.nlm.nih.gov/pubmed/36815162
http://dx.doi.org/10.3389/fpubh.2023.1095343
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