Efficient Downregulation of Alk4 in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular Dystrophy

Downregulation of genes involved in the secondary pathology of Duchenne muscular dystrophy, for example, inflammation, fibrosis, and adiposis, is an interesting approach to ameliorate degeneration of muscle and replacement by fibrotic and adiposis tissue. Small interfering RNAs (siRNAs) are able to...

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Detalles Bibliográficos
Autores principales: Engelbeen, Sarah, Pasteuning-Vuhman, Svetlana, Boertje-van der Meulen, Joke, Parmar, Rubina, Charisse, Klaus, Sepp-Lorenzino, Laura, Manoharan, Muthiah, Aartsma-Rus, Annemieke, van Putten, Maaike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940804/
https://www.ncbi.nlm.nih.gov/pubmed/36269327
http://dx.doi.org/10.1089/nat.2022.0021

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