Cargando…

Elevation of SHANK3 Levels by Antisense Oligonucleotides Directed Against the 3′-UTR of the Human SHANK3 mRNA

SHANK3 is a member of the SHANK family of scaffolding proteins that localize to the postsynaptic density of excitatory synapses. Mutations within the SHANK3 gene or SHANK3 haploinsufficiency is thought to be one of the major causes for Phelan-McDermid Syndrome (PMDS) that is characterized by a broad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stirmlinger, Nadine, Delling, Jan Philip, Pfänder, Stefanie, Boeckers, Tobias M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2023
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940809/ https://www.ncbi.nlm.nih.gov/pubmed/36355061 http://dx.doi.org/10.1089/nat.2022.0048

Ejemplares similares

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications
por: Delling, Jan Philipp, et al.
Publicado: (2021)

SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice
por: Lutz, Anne-Kathrin, et al.
Publicado: (2021)

Development of sex- and genotype-specific behavioral phenotypes in a Shank3 mouse model for neurodevelopmental disorders
por: Bauer, Helen Friedericke, et al.
Publicado: (2023)

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
por: Wang, Li, et al.
Publicado: (2019)

SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system
por: Malara, Mariagiovanna, et al.
Publicado: (2022)

SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry
por: Lutz, Anne-Kathrin, et al.
Publicado: (2022)

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice
por: Wang, Xiaoming, et al.
Publicado: (2014)

The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons
por: Reim, Dominik, et al.
Publicado: (2016)

Single-molecule fluorescence in-situ hybridization reveals that human SHANK3 mRNA expression varies during development and in autism-associated SHANK3 heterozygosity
por: Taylor, Samuel E., et al.
Publicado: (2018)

Restoring Shank3 in the rostral brainstem of shank3ab−/− zebrafish autism models rescues sensory deficits
por: Kozol, Robert A., et al.
Publicado: (2021)

The Shank3(Venus/Venus) knock in mouse enables isoform-specific functional studies of Shank3a
por: Bouquier, Nathalie, et al.
Publicado: (2022)

Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism
por: James, David M., et al.
Publicado: (2019)

Unexpected Compensatory Increase in Shank3 Transcripts in Shank3 Knock-Out Mice Having Partial Deletions of Exons
por: Jin, Chunmei, et al.
Publicado: (2019)

Editorial: Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases
por: Ey, Elodie, et al.
Publicado: (2020)

Expression profiles of the autism-related SHANK proteins in the human brain
por: Woelfle, Sarah, et al.
Publicado: (2023)

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling
por: Lee, Yeunkum, et al.
Publicado: (2017)

Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID
por: Cochoy, Daniela M, et al.
Publicado: (2015)

Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice
por: Han, Kyung Ah, et al.
Publicado: (2020)

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice
por: Atanasova, Ekaterina, et al.
Publicado: (2023)

Severe white matter damage in SHANK3 deficiency: a human and translational study
por: Jesse, Sarah, et al.
Publicado: (2019)

Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model
por: Sauer, Ann Katrin, et al.
Publicado: (2019)

Downregulation of the Autism Spectrum Disorder Gene Shank2 Decreases Bone Mass in Male Mice
por: Ahmad, Mubashir, et al.
Publicado: (2022)

Shank3 influences mammalian sleep development
por: Medina, Elizabeth, et al.
Publicado: (2022)

Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations
por: Lee, Yeunkum, et al.
Publicado: (2017)

Early Restoration of Shank3 Expression in Shank3 Knock-Out Mice Prevents Core ASD-Like Behavioral Phenotypes
por: Jaramillo, Thomas C., et al.
Publicado: (2020)

Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3
por: Pfaender, Stefanie, et al.
Publicado: (2017)

Deletion of the Autism-Associated Protein SHANK3 Abolishes Structural Synaptic Plasticity after Brain Trauma
por: Urrutia-Ruiz, Carolina, et al.
Publicado: (2022)

The emerging roles of Shank3 in cardiac function and dysfunction
por: Kim, Yoonhee, et al.
Publicado: (2023)

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
por: Schuetz, Gunnar, et al.
Publicado: (2004)

William Frederick Shanks
Publicado: (1926)

Lack of Association between NLGN3, NLGN4, SHANK2 and SHANK3 Gene Variants and Autism Spectrum Disorder in a Chinese Population
por: Liu, Yanyan, et al.
Publicado: (2013)

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice
por: Vicidomini, Cinzia, et al.
Publicado: (2016)

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras
por: Lilja, Johanna, et al.
Publicado: (2017)

Shank3 related muscular hypotonia is accompanied by increased intracellular calcium concentrations and ion channel dysregulation in striated muscle tissue
por: Yildiz, Berra, et al.
Publicado: (2023)

Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses
por: Tao-Cheng, Jung-Hwa, et al.
Publicado: (2016)

SHANK3 controls maturation of social reward circuits in the VTA
por: Bariselli, Sebastiano, et al.
Publicado: (2016)

Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice
por: Chiesa, Morgane, et al.
Publicado: (2019)

Shank3 modulates sleep and expression of circadian transcription factors
por: Ingiosi, Ashley M, et al.
Publicado: (2019)

Altered Light Sensitivity of Circadian Clock in Shank3(+/–) Mouse
por: Alamilla, Javier, et al.
Publicado: (2021)

CaMKII Phosphorylation Regulates Synaptic Enrichment of Shank3
por: Jeong, Jaehoon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g8a7o3dc756qbs9tksjc4sfb4q