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Mechanisms of robustness in gene regulatory networks involved in neural development

The functions of living organisms are affected by different kinds of perturbation, both internal and external, which in many cases have functional effects and phenotypic impact. The effects of these perturbations become particularly relevant for multicellular organisms with complex body patterns and...

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Autores principales: Arcuschin, Camila D., Pinkasz, Marina, Schor, Ignacio E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940843/
https://www.ncbi.nlm.nih.gov/pubmed/36814969
http://dx.doi.org/10.3389/fnmol.2023.1114015
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author Arcuschin, Camila D.
Pinkasz, Marina
Schor, Ignacio E.
author_facet Arcuschin, Camila D.
Pinkasz, Marina
Schor, Ignacio E.
author_sort Arcuschin, Camila D.
collection PubMed
description The functions of living organisms are affected by different kinds of perturbation, both internal and external, which in many cases have functional effects and phenotypic impact. The effects of these perturbations become particularly relevant for multicellular organisms with complex body patterns and cell type heterogeneity, where transcriptional programs controlled by gene regulatory networks determine, for example, the cell fate during embryonic development. Therefore, an essential aspect of development in these organisms is the ability to maintain the functionality of their genetic developmental programs even in the presence of genetic variation, changing environmental conditions and biochemical noise, a property commonly termed robustness. We discuss the implication of different molecular mechanisms of robustness involved in neurodevelopment, which is characterized by the interplay of many developmental programs at a molecular, cellular and systemic level. We specifically focus on processes affecting the function of gene regulatory networks, encompassing transcriptional regulatory elements and post-transcriptional processes such as miRNA-based regulation, but also higher order regulatory organization, such as gene network topology. We also present cases where impairment of robustness mechanisms can be associated with neurodevelopmental disorders, as well as reasons why understanding these mechanisms should represent an important part of the study of gene regulatory networks driving neural development.
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spelling pubmed-99408432023-02-21 Mechanisms of robustness in gene regulatory networks involved in neural development Arcuschin, Camila D. Pinkasz, Marina Schor, Ignacio E. Front Mol Neurosci Molecular Neuroscience The functions of living organisms are affected by different kinds of perturbation, both internal and external, which in many cases have functional effects and phenotypic impact. The effects of these perturbations become particularly relevant for multicellular organisms with complex body patterns and cell type heterogeneity, where transcriptional programs controlled by gene regulatory networks determine, for example, the cell fate during embryonic development. Therefore, an essential aspect of development in these organisms is the ability to maintain the functionality of their genetic developmental programs even in the presence of genetic variation, changing environmental conditions and biochemical noise, a property commonly termed robustness. We discuss the implication of different molecular mechanisms of robustness involved in neurodevelopment, which is characterized by the interplay of many developmental programs at a molecular, cellular and systemic level. We specifically focus on processes affecting the function of gene regulatory networks, encompassing transcriptional regulatory elements and post-transcriptional processes such as miRNA-based regulation, but also higher order regulatory organization, such as gene network topology. We also present cases where impairment of robustness mechanisms can be associated with neurodevelopmental disorders, as well as reasons why understanding these mechanisms should represent an important part of the study of gene regulatory networks driving neural development. Frontiers Media S.A. 2023-02-06 /pmc/articles/PMC9940843/ /pubmed/36814969 http://dx.doi.org/10.3389/fnmol.2023.1114015 Text en Copyright © 2023 Arcuschin, Pinkasz and Schor. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Arcuschin, Camila D.
Pinkasz, Marina
Schor, Ignacio E.
Mechanisms of robustness in gene regulatory networks involved in neural development
title Mechanisms of robustness in gene regulatory networks involved in neural development
title_full Mechanisms of robustness in gene regulatory networks involved in neural development
title_fullStr Mechanisms of robustness in gene regulatory networks involved in neural development
title_full_unstemmed Mechanisms of robustness in gene regulatory networks involved in neural development
title_short Mechanisms of robustness in gene regulatory networks involved in neural development
title_sort mechanisms of robustness in gene regulatory networks involved in neural development
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940843/
https://www.ncbi.nlm.nih.gov/pubmed/36814969
http://dx.doi.org/10.3389/fnmol.2023.1114015
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