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Pallidal neuromodulation of the explore/exploit trade-off in decision-making

Every decision that we make involves a conflict between exploiting our current knowledge of an action’s value or exploring alternative courses of action that might lead to a better, or worse outcome. The sub-cortical nuclei that make up the basal ganglia have been proposed as a neural circuit that m...

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Autores principales: de A Marcelino, Ana Luisa, Gray, Owen, Al-Fatly, Bassam, Gilmour, William, Douglas Steele, J, Kühn, Andrea A, Gilbertson, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940911/
https://www.ncbi.nlm.nih.gov/pubmed/36727860
http://dx.doi.org/10.7554/eLife.79642
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author de A Marcelino, Ana Luisa
Gray, Owen
Al-Fatly, Bassam
Gilmour, William
Douglas Steele, J
Kühn, Andrea A
Gilbertson, Tom
author_facet de A Marcelino, Ana Luisa
Gray, Owen
Al-Fatly, Bassam
Gilmour, William
Douglas Steele, J
Kühn, Andrea A
Gilbertson, Tom
author_sort de A Marcelino, Ana Luisa
collection PubMed
description Every decision that we make involves a conflict between exploiting our current knowledge of an action’s value or exploring alternative courses of action that might lead to a better, or worse outcome. The sub-cortical nuclei that make up the basal ganglia have been proposed as a neural circuit that may contribute to resolving this explore-exploit ‘dilemma’. To test this hypothesis, we examined the effects of neuromodulating the basal ganglia’s output nucleus, the globus pallidus interna, in patients who had undergone deep brain stimulation (DBS) for isolated dystonia. Neuromodulation enhanced the number of exploratory choices to the lower value option in a two-armed bandit probabilistic reversal-learning task. Enhanced exploration was explained by a reduction in the rate of evidence accumulation (drift rate) in a reinforcement learning drift diffusion model. We estimated the functional connectivity profile between the stimulating DBS electrode and the rest of the brain using a normative functional connectome derived from heathy controls. Variation in the extent of neuromodulation induced exploration between patients was associated with functional connectivity from the stimulation electrode site to a distributed brain functional network. We conclude that the basal ganglia’s output nucleus, the globus pallidus interna, can adaptively modify decision choice when faced with the dilemma to explore or exploit.
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spelling pubmed-99409112023-02-21 Pallidal neuromodulation of the explore/exploit trade-off in decision-making de A Marcelino, Ana Luisa Gray, Owen Al-Fatly, Bassam Gilmour, William Douglas Steele, J Kühn, Andrea A Gilbertson, Tom eLife Neuroscience Every decision that we make involves a conflict between exploiting our current knowledge of an action’s value or exploring alternative courses of action that might lead to a better, or worse outcome. The sub-cortical nuclei that make up the basal ganglia have been proposed as a neural circuit that may contribute to resolving this explore-exploit ‘dilemma’. To test this hypothesis, we examined the effects of neuromodulating the basal ganglia’s output nucleus, the globus pallidus interna, in patients who had undergone deep brain stimulation (DBS) for isolated dystonia. Neuromodulation enhanced the number of exploratory choices to the lower value option in a two-armed bandit probabilistic reversal-learning task. Enhanced exploration was explained by a reduction in the rate of evidence accumulation (drift rate) in a reinforcement learning drift diffusion model. We estimated the functional connectivity profile between the stimulating DBS electrode and the rest of the brain using a normative functional connectome derived from heathy controls. Variation in the extent of neuromodulation induced exploration between patients was associated with functional connectivity from the stimulation electrode site to a distributed brain functional network. We conclude that the basal ganglia’s output nucleus, the globus pallidus interna, can adaptively modify decision choice when faced with the dilemma to explore or exploit. eLife Sciences Publications, Ltd 2023-02-02 /pmc/articles/PMC9940911/ /pubmed/36727860 http://dx.doi.org/10.7554/eLife.79642 Text en © 2023, de A Marcelino et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
de A Marcelino, Ana Luisa
Gray, Owen
Al-Fatly, Bassam
Gilmour, William
Douglas Steele, J
Kühn, Andrea A
Gilbertson, Tom
Pallidal neuromodulation of the explore/exploit trade-off in decision-making
title Pallidal neuromodulation of the explore/exploit trade-off in decision-making
title_full Pallidal neuromodulation of the explore/exploit trade-off in decision-making
title_fullStr Pallidal neuromodulation of the explore/exploit trade-off in decision-making
title_full_unstemmed Pallidal neuromodulation of the explore/exploit trade-off in decision-making
title_short Pallidal neuromodulation of the explore/exploit trade-off in decision-making
title_sort pallidal neuromodulation of the explore/exploit trade-off in decision-making
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940911/
https://www.ncbi.nlm.nih.gov/pubmed/36727860
http://dx.doi.org/10.7554/eLife.79642
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