Efficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised controlled trials

BACKGROUND: In a phase 2b trial and the phase 3 MELODY trial, nirsevimab, an extended half-life, monoclonal antibody against respiratory syncytial virus (RSV), protected healthy infants born preterm or at full term against medically attended RSV lower respiratory tract infection (LRTI). In the MEDLE...

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Detalles Bibliográficos
Autores principales: Simões, Eric A F, Madhi, Shabir A, Muller, William J, Atanasova, Victoria, Bosheva, Miroslava, Cabañas, Fernando, Baca Cots, Manuel, Domachowske, Joseph B, Garcia-Garcia, Maria L, Grantina, Ineta, Nguyen, Kim A, Zar, Heather J, Berglind, Anna, Cummings, Celeste, Griffin, M Pamela, Takas, Therese, Yuan, Yuan, Wählby Hamrén, Ulrika, Leach, Amanda, Villafana, Tonya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940918/
https://www.ncbi.nlm.nih.gov/pubmed/36634694
http://dx.doi.org/10.1016/S2352-4642(22)00321-2

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