Cargando…

Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells

The traditional Mediterranean diet (MD) is characterized by a high phenolic-rich food intake, including in particular vegetables and fruits, but also legumes, whole grain cereals, nuts, and extra virgin olive oil. Evidence for beneficial effects of polyphenols in humans depends on the amount consume...

Descripción completa

Detalles Bibliográficos
Autores principales: Augimeri, Giuseppina, Avolio, Ennio, Caparello, Giovanna, Galluccio, Angelo, De Rose, Daniela, Vivacqua, Adele, Morelli, Catia, Barone, Ines, Catalano, Stefania, Andò, Sebastiano, Giordano, Cinzia, Sisci, Diego, D'Angelo, Stefania, Bonofiglio, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940959/
https://www.ncbi.nlm.nih.gov/pubmed/36814955
http://dx.doi.org/10.1155/2023/1555942
_version_ 1784891182201962496
author Augimeri, Giuseppina
Avolio, Ennio
Caparello, Giovanna
Galluccio, Angelo
De Rose, Daniela
Vivacqua, Adele
Morelli, Catia
Barone, Ines
Catalano, Stefania
Andò, Sebastiano
Giordano, Cinzia
Sisci, Diego
D'Angelo, Stefania
Bonofiglio, Daniela
author_facet Augimeri, Giuseppina
Avolio, Ennio
Caparello, Giovanna
Galluccio, Angelo
De Rose, Daniela
Vivacqua, Adele
Morelli, Catia
Barone, Ines
Catalano, Stefania
Andò, Sebastiano
Giordano, Cinzia
Sisci, Diego
D'Angelo, Stefania
Bonofiglio, Daniela
author_sort Augimeri, Giuseppina
collection PubMed
description The traditional Mediterranean diet (MD) is characterized by a high phenolic-rich food intake, including in particular vegetables and fruits, but also legumes, whole grain cereals, nuts, and extra virgin olive oil. Evidence for beneficial effects of polyphenols in humans depends on the amount consumed and on their bioavailability. Here, we evaluated the association between the estimated polyphenol intake by fruits and vegetables food source and serum biochemical parameters in healthy adolescents, recruited into the DIMENU research project. Categorizing adolescents into three groups according to their estimated total polyphenol intake, we found that adolescents who declared high consumption of polyphenols had a higher adherence to the MD and had a better serum lipid profile than adolescents consuming low amounts of polyphenols. Moreover, using human HepG2 liver cells treated with oleic acid as an in vitro model for studying lipid accumulation, we showed that intracellular lipid accumulation is alleviated by serum from adolescents consuming a polyphenol-rich diet following MD recommendations. Our data underline the importance of promoting adherence to the typical MD foods as a superior strategy to prevent metabolic and chronic diseases and to ensure a better quality of life among adolescents.
format Online
Article
Text
id pubmed-9940959
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-99409592023-02-21 Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells Augimeri, Giuseppina Avolio, Ennio Caparello, Giovanna Galluccio, Angelo De Rose, Daniela Vivacqua, Adele Morelli, Catia Barone, Ines Catalano, Stefania Andò, Sebastiano Giordano, Cinzia Sisci, Diego D'Angelo, Stefania Bonofiglio, Daniela Oxid Med Cell Longev Research Article The traditional Mediterranean diet (MD) is characterized by a high phenolic-rich food intake, including in particular vegetables and fruits, but also legumes, whole grain cereals, nuts, and extra virgin olive oil. Evidence for beneficial effects of polyphenols in humans depends on the amount consumed and on their bioavailability. Here, we evaluated the association between the estimated polyphenol intake by fruits and vegetables food source and serum biochemical parameters in healthy adolescents, recruited into the DIMENU research project. Categorizing adolescents into three groups according to their estimated total polyphenol intake, we found that adolescents who declared high consumption of polyphenols had a higher adherence to the MD and had a better serum lipid profile than adolescents consuming low amounts of polyphenols. Moreover, using human HepG2 liver cells treated with oleic acid as an in vitro model for studying lipid accumulation, we showed that intracellular lipid accumulation is alleviated by serum from adolescents consuming a polyphenol-rich diet following MD recommendations. Our data underline the importance of promoting adherence to the typical MD foods as a superior strategy to prevent metabolic and chronic diseases and to ensure a better quality of life among adolescents. Hindawi 2023-02-13 /pmc/articles/PMC9940959/ /pubmed/36814955 http://dx.doi.org/10.1155/2023/1555942 Text en Copyright © 2023 Giuseppina Augimeri et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Augimeri, Giuseppina
Avolio, Ennio
Caparello, Giovanna
Galluccio, Angelo
De Rose, Daniela
Vivacqua, Adele
Morelli, Catia
Barone, Ines
Catalano, Stefania
Andò, Sebastiano
Giordano, Cinzia
Sisci, Diego
D'Angelo, Stefania
Bonofiglio, Daniela
Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells
title Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells
title_full Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells
title_fullStr Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells
title_full_unstemmed Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells
title_short Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells
title_sort serum from adolescents with high polyphenol intake exhibits improved lipid profile and prevents lipid accumulation in hepg2 human liver cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940959/
https://www.ncbi.nlm.nih.gov/pubmed/36814955
http://dx.doi.org/10.1155/2023/1555942
work_keys_str_mv AT augimerigiuseppina serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT avolioennio serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT caparellogiovanna serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT galluccioangelo serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT derosedaniela serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT vivacquaadele serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT morellicatia serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT baroneines serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT catalanostefania serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT andosebastiano serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT giordanocinzia serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT siscidiego serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT dangelostefania serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells
AT bonofigliodaniela serumfromadolescentswithhighpolyphenolintakeexhibitsimprovedlipidprofileandpreventslipidaccumulationinhepg2humanlivercells