A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells

Alternative Lengthening of Telomeres (ALT) is an aberrant DNA recombination pathway which grants replicative immortality to approximately 10% of all cancers. Despite this high prevalence of ALT in cancer, the mechanism and genetics by which cells activate this pathway remain incompletely understood....

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Detalles Bibliográficos
Autores principales: Turkalo, Timothy K., Maffia, Antonio, Schabort, Johannes J., Regalado, Samuel G., Bhakta, Mital, Blanchette, Marco, Spierings, Diana C. J., Lansdorp, Peter M., Hockemeyer, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941109/
https://www.ncbi.nlm.nih.gov/pubmed/36805596
http://dx.doi.org/10.1038/s41467-023-36294-6

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