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Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases

Huntingtin-associated protein 1 (HAP1), the first identified HTT-binding partner, is highly expressed in the central nervous system, and has been found to associated with neurological diseases. Mounting evidence suggests that HAP1 functions as a component of cargo-motor molecules to bind various pro...

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Autores principales: Chen, Xingxing, He, Enhao, Su, Chonglin, Zeng, Yan, Xu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941194/
https://www.ncbi.nlm.nih.gov/pubmed/36824265
http://dx.doi.org/10.3389/fnagi.2023.1100395
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author Chen, Xingxing
He, Enhao
Su, Chonglin
Zeng, Yan
Xu, Jiang
author_facet Chen, Xingxing
He, Enhao
Su, Chonglin
Zeng, Yan
Xu, Jiang
author_sort Chen, Xingxing
collection PubMed
description Huntingtin-associated protein 1 (HAP1), the first identified HTT-binding partner, is highly expressed in the central nervous system, and has been found to associated with neurological diseases. Mounting evidence suggests that HAP1 functions as a component of cargo-motor molecules to bind various proteins and participates in intracellular trafficking. It is known that the failure of intracellular transport is a key contributor to the progression of neurodegenerative disorders (NDs) including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), spinal and bulbar muscular atrophy (SBMA) and spinocerebellar ataxia (SCA). The link between HAP1 and various NDs is supported by growing evidence. This review aims to provide a comprehensive overview of the intracellular trafficking function of HAP1 and its involvement in NDs.
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spelling pubmed-99411942023-02-22 Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases Chen, Xingxing He, Enhao Su, Chonglin Zeng, Yan Xu, Jiang Front Aging Neurosci Aging Neuroscience Huntingtin-associated protein 1 (HAP1), the first identified HTT-binding partner, is highly expressed in the central nervous system, and has been found to associated with neurological diseases. Mounting evidence suggests that HAP1 functions as a component of cargo-motor molecules to bind various proteins and participates in intracellular trafficking. It is known that the failure of intracellular transport is a key contributor to the progression of neurodegenerative disorders (NDs) including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), spinal and bulbar muscular atrophy (SBMA) and spinocerebellar ataxia (SCA). The link between HAP1 and various NDs is supported by growing evidence. This review aims to provide a comprehensive overview of the intracellular trafficking function of HAP1 and its involvement in NDs. Frontiers Media S.A. 2023-02-07 /pmc/articles/PMC9941194/ /pubmed/36824265 http://dx.doi.org/10.3389/fnagi.2023.1100395 Text en Copyright © 2023 Chen, He, Su, Zeng and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Chen, Xingxing
He, Enhao
Su, Chonglin
Zeng, Yan
Xu, Jiang
Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
title Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
title_full Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
title_fullStr Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
title_full_unstemmed Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
title_short Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
title_sort huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941194/
https://www.ncbi.nlm.nih.gov/pubmed/36824265
http://dx.doi.org/10.3389/fnagi.2023.1100395
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