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Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer

BACKGROUND: Cetuximab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR), is effective for RAS wild-type metastatic colorectal cancer (mCRC) patients. However, cetuximab resistance often occur and the mechanism has not been fully elucidated. The purpose of this study was to inv...

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Detalles Bibliográficos
Autores principales:	Xu, Xiaojing, Liu, Mengling, Peng, Ke, Yu, Yiyi, Liu, Tianshu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941237/ https://www.ncbi.nlm.nih.gov/pubmed/36609651 http://dx.doi.org/10.1007/s12094-022-02986-6

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