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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Serine hydroxymethyltransferase 2 (SHMT2) plays an important role in converting serine to glycine and supplying carbon to one-carbon metabolism to sustain cancer cell proliferation. However, the expression, function, and underlying mechanisms of SHMT2 in clear cell renal cell carcinoma (ccRCC) remai...

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Detalles Bibliográficos
Autores principales:	Liu, Zhangnan, Fan, Mengzhen, Hou, Junqing, Pan, Sijing, Xu, Yanxin, Zhang, Hailong, Liu, Chen, Hao, Xiangjun, Li, Xia, Wang, Huijuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941282/ https://www.ncbi.nlm.nih.gov/pubmed/36806313 http://dx.doi.org/10.1038/s41419-023-05677-4

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