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The safe and effective use of supercritical CO(2)-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study
INTRODUCTION: The clinical efficacy and safety of supercritical CO(2)-processed bone allografts prepared from living donors has yet to be confirmed in spinal surgery. Here we report our clinical and surgical experience of using supercritical CO(2)-processed bone allografts for lumbar and cervical fu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941326/ https://www.ncbi.nlm.nih.gov/pubmed/36824495 http://dx.doi.org/10.3389/fsurg.2023.984028 |
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author | Aurouer, Nicolas Guerin, Patrick Cogniet, Arnaud Pedram, Morad |
author_facet | Aurouer, Nicolas Guerin, Patrick Cogniet, Arnaud Pedram, Morad |
author_sort | Aurouer, Nicolas |
collection | PubMed |
description | INTRODUCTION: The clinical efficacy and safety of supercritical CO(2)-processed bone allografts prepared from living donors has yet to be confirmed in spinal surgery. Here we report our clinical and surgical experience of using supercritical CO(2)-processed bone allografts for lumbar and cervical fusion. METHODS: Sixteen patients underwent one or two level anterior cervical discectomy and fusion and 37 patients underwent anterior retroperitoneal route lumbar fusion using bone allografts processed using supercritical CO(2) extraction combined with chemical viral inactivation. Fusion success was assessed radiographically in the immediate postoperative period and at one month, six months, one year, and three years postoperatively. Function and pain were assessed using visual analog scales, Odom's criteria, the neck disability index (NDI), and the Oswestry disability index (ODI). RESULTS: At a mean of 43 and 47 months postoperatively, 95.3% and 90.5% of cervical and lumbar fusion patients had radiographic evidence of bone fusion, respectively. Over 80% of patients reported good to excellent outcomes according to Odom's criteria, the perception of pain significantly decreased, and the mean NDI and ODI scores significantly improved at the last follow-up compared with before the operations. There were no safety concerns. For the cervical group, the mean NDI score improved from 26.3 ± 6.01 preoperatively to 15.00 ± 8.03 and 17.60 ± 13.95 at immediate post-op (p = 0.02) and last follow-up visits (p = 0.037) respectively. For the lumbar cases, the mean ODI score improved from 28.31 ± 6.48 preoperatively to 14.68 ± 5.49 (p < 0.0001) and 12.54 ± 10.21 (p < 00001) at immediate post-op and last follow-up visits respectively. CONCLUSION: Within the limitations of this study, the use of supercritical CO(2)-processed bone allografts resulted in satisfactory clinical outcomes and fusion rates with acceptable safety for both cervical and lumbar surgeries. |
format | Online Article Text |
id | pubmed-9941326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99413262023-02-22 The safe and effective use of supercritical CO(2)-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study Aurouer, Nicolas Guerin, Patrick Cogniet, Arnaud Pedram, Morad Front Surg Surgery INTRODUCTION: The clinical efficacy and safety of supercritical CO(2)-processed bone allografts prepared from living donors has yet to be confirmed in spinal surgery. Here we report our clinical and surgical experience of using supercritical CO(2)-processed bone allografts for lumbar and cervical fusion. METHODS: Sixteen patients underwent one or two level anterior cervical discectomy and fusion and 37 patients underwent anterior retroperitoneal route lumbar fusion using bone allografts processed using supercritical CO(2) extraction combined with chemical viral inactivation. Fusion success was assessed radiographically in the immediate postoperative period and at one month, six months, one year, and three years postoperatively. Function and pain were assessed using visual analog scales, Odom's criteria, the neck disability index (NDI), and the Oswestry disability index (ODI). RESULTS: At a mean of 43 and 47 months postoperatively, 95.3% and 90.5% of cervical and lumbar fusion patients had radiographic evidence of bone fusion, respectively. Over 80% of patients reported good to excellent outcomes according to Odom's criteria, the perception of pain significantly decreased, and the mean NDI and ODI scores significantly improved at the last follow-up compared with before the operations. There were no safety concerns. For the cervical group, the mean NDI score improved from 26.3 ± 6.01 preoperatively to 15.00 ± 8.03 and 17.60 ± 13.95 at immediate post-op (p = 0.02) and last follow-up visits (p = 0.037) respectively. For the lumbar cases, the mean ODI score improved from 28.31 ± 6.48 preoperatively to 14.68 ± 5.49 (p < 0.0001) and 12.54 ± 10.21 (p < 00001) at immediate post-op and last follow-up visits respectively. CONCLUSION: Within the limitations of this study, the use of supercritical CO(2)-processed bone allografts resulted in satisfactory clinical outcomes and fusion rates with acceptable safety for both cervical and lumbar surgeries. Frontiers Media S.A. 2023-02-07 /pmc/articles/PMC9941326/ /pubmed/36824495 http://dx.doi.org/10.3389/fsurg.2023.984028 Text en © 2023 Pedram. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Aurouer, Nicolas Guerin, Patrick Cogniet, Arnaud Pedram, Morad The safe and effective use of supercritical CO(2)-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study |
title | The safe and effective use of supercritical CO(2)-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study |
title_full | The safe and effective use of supercritical CO(2)-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study |
title_fullStr | The safe and effective use of supercritical CO(2)-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study |
title_full_unstemmed | The safe and effective use of supercritical CO(2)-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study |
title_short | The safe and effective use of supercritical CO(2)-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study |
title_sort | safe and effective use of supercritical co(2)-processed bone allografts for cervical and lumbar interbody fusion: a retrospective study |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941326/ https://www.ncbi.nlm.nih.gov/pubmed/36824495 http://dx.doi.org/10.3389/fsurg.2023.984028 |
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