Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge

This is a case of [(68) Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This i...

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Detalles Bibliográficos
Autores principales: Vetrone, Luigia, Cuzzani, Giulia, Mei, Riccardo, Zanoni, Lucia, Bertaccini, Alessandro, Bianchi, Lorenzo, Castellucci, Paolo, Gaudiano, Caterina, Cappelli, Alberta, Giunchi, Francesca, Fanti, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941543/
https://www.ncbi.nlm.nih.gov/pubmed/36824128
http://dx.doi.org/10.3389/fonc.2023.1101221
Descripción
Sumario:This is a case of [(68) Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This is a highly interesting case because, despite the advanced metastatic spread at initial presentation as showed by [(68)Ga]Ga-PSMA-PET/CT, the primary Pca was detected by none of the diagnostic techniques (12 random sample biopsy, mpMRI, PSMA PET/CT). However, [(68)Ga]Ga-PSMA-PET/CT showed a suspicious axillary lesion suitable for biopsy, which finally resulted as Pca metastasis. This case report is therefore a brilliant example of how [(68)Ga]Ga-PSMA-PET/CT optimized patient’s management.

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