Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge

This is a case of [(68) Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This i...

Descripción completa

Detalles Bibliográficos
Autores principales: Vetrone, Luigia, Cuzzani, Giulia, Mei, Riccardo, Zanoni, Lucia, Bertaccini, Alessandro, Bianchi, Lorenzo, Castellucci, Paolo, Gaudiano, Caterina, Cappelli, Alberta, Giunchi, Francesca, Fanti, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941543/
https://www.ncbi.nlm.nih.gov/pubmed/36824128
http://dx.doi.org/10.3389/fonc.2023.1101221
_version_ 1784891306868211712
author Vetrone, Luigia
Cuzzani, Giulia
Mei, Riccardo
Zanoni, Lucia
Bertaccini, Alessandro
Bianchi, Lorenzo
Castellucci, Paolo
Gaudiano, Caterina
Cappelli, Alberta
Giunchi, Francesca
Fanti, Stefano
author_facet Vetrone, Luigia
Cuzzani, Giulia
Mei, Riccardo
Zanoni, Lucia
Bertaccini, Alessandro
Bianchi, Lorenzo
Castellucci, Paolo
Gaudiano, Caterina
Cappelli, Alberta
Giunchi, Francesca
Fanti, Stefano
author_sort Vetrone, Luigia
collection PubMed
description This is a case of [(68) Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This is a highly interesting case because, despite the advanced metastatic spread at initial presentation as showed by [(68)Ga]Ga-PSMA-PET/CT, the primary Pca was detected by none of the diagnostic techniques (12 random sample biopsy, mpMRI, PSMA PET/CT). However, [(68)Ga]Ga-PSMA-PET/CT showed a suspicious axillary lesion suitable for biopsy, which finally resulted as Pca metastasis. This case report is therefore a brilliant example of how [(68)Ga]Ga-PSMA-PET/CT optimized patient’s management.
format Online
Article
Text
id pubmed-9941543
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99415432023-02-22 Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge Vetrone, Luigia Cuzzani, Giulia Mei, Riccardo Zanoni, Lucia Bertaccini, Alessandro Bianchi, Lorenzo Castellucci, Paolo Gaudiano, Caterina Cappelli, Alberta Giunchi, Francesca Fanti, Stefano Front Oncol Oncology This is a case of [(68) Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This is a highly interesting case because, despite the advanced metastatic spread at initial presentation as showed by [(68)Ga]Ga-PSMA-PET/CT, the primary Pca was detected by none of the diagnostic techniques (12 random sample biopsy, mpMRI, PSMA PET/CT). However, [(68)Ga]Ga-PSMA-PET/CT showed a suspicious axillary lesion suitable for biopsy, which finally resulted as Pca metastasis. This case report is therefore a brilliant example of how [(68)Ga]Ga-PSMA-PET/CT optimized patient’s management. Frontiers Media S.A. 2023-02-07 /pmc/articles/PMC9941543/ /pubmed/36824128 http://dx.doi.org/10.3389/fonc.2023.1101221 Text en Copyright © 2023 Vetrone, Cuzzani, Mei, Zanoni, Bertaccini, Bianchi, Castellucci, Gaudiano, Cappelli, Giunchi and Fanti https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Vetrone, Luigia
Cuzzani, Giulia
Mei, Riccardo
Zanoni, Lucia
Bertaccini, Alessandro
Bianchi, Lorenzo
Castellucci, Paolo
Gaudiano, Caterina
Cappelli, Alberta
Giunchi, Francesca
Fanti, Stefano
Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge
title Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge
title_full Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge
title_fullStr Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge
title_full_unstemmed Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge
title_short Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge
title_sort case report: psma pet/ct addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpmri. a diagnostic challenge
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941543/
https://www.ncbi.nlm.nih.gov/pubmed/36824128
http://dx.doi.org/10.3389/fonc.2023.1101221
work_keys_str_mv AT vetroneluigia casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT cuzzanigiulia casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT meiriccardo casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT zanonilucia casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT bertaccinialessandro casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT bianchilorenzo casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT castelluccipaolo casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT gaudianocaterina casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT cappellialberta casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT giunchifrancesca casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge
AT fantistefano casereportpsmapetctaddressesthecorrectdiagnosisinapatientwithmetastaticprostatecancerdespitenegativecorebiopsiesandmpmriadiagnosticchallenge

Ejemplares similares