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Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review
Osteoarthritis is a chronic degenerative joint disease that exerts significant impacts on personal life quality, and cartilage tissue engineering is a practical treatment in clinical. Various growth factors are involved in cartilage regeneration and play important roles therein, which is the focus o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941568/ https://www.ncbi.nlm.nih.gov/pubmed/36824354 http://dx.doi.org/10.3389/fbioe.2023.1127949 |
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author | Qin, Shengao Zhu, Jiaman Zhang, Guangyong Sui, Qijia Niu, Yimeng Ye, Weilong Ma, Guowu Liu, Huiying |
author_facet | Qin, Shengao Zhu, Jiaman Zhang, Guangyong Sui, Qijia Niu, Yimeng Ye, Weilong Ma, Guowu Liu, Huiying |
author_sort | Qin, Shengao |
collection | PubMed |
description | Osteoarthritis is a chronic degenerative joint disease that exerts significant impacts on personal life quality, and cartilage tissue engineering is a practical treatment in clinical. Various growth factors are involved in cartilage regeneration and play important roles therein, which is the focus of current cartilage repair strategy. To compensate for the purification difficulty, high cost, poor metabolic stability, and circulating dilution of natural growth factors, the concept of functional motifs (also known as mimetic peptides) from original growth factor was introduced in recent studies. Here, we reviewed the selection mechanisms, biological functions, carrier scaffolds, and modification methods of growth factor-related functional motifs, and evaluated the repair performance in cartilage tissue engineering. Finally, the prospects of functional motifs in researches and clinical application were discussed. |
format | Online Article Text |
id | pubmed-9941568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99415682023-02-22 Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review Qin, Shengao Zhu, Jiaman Zhang, Guangyong Sui, Qijia Niu, Yimeng Ye, Weilong Ma, Guowu Liu, Huiying Front Bioeng Biotechnol Bioengineering and Biotechnology Osteoarthritis is a chronic degenerative joint disease that exerts significant impacts on personal life quality, and cartilage tissue engineering is a practical treatment in clinical. Various growth factors are involved in cartilage regeneration and play important roles therein, which is the focus of current cartilage repair strategy. To compensate for the purification difficulty, high cost, poor metabolic stability, and circulating dilution of natural growth factors, the concept of functional motifs (also known as mimetic peptides) from original growth factor was introduced in recent studies. Here, we reviewed the selection mechanisms, biological functions, carrier scaffolds, and modification methods of growth factor-related functional motifs, and evaluated the repair performance in cartilage tissue engineering. Finally, the prospects of functional motifs in researches and clinical application were discussed. Frontiers Media S.A. 2023-02-07 /pmc/articles/PMC9941568/ /pubmed/36824354 http://dx.doi.org/10.3389/fbioe.2023.1127949 Text en Copyright © 2023 Qin, Zhu, Zhang, Sui, Niu, Ye, Ma and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Qin, Shengao Zhu, Jiaman Zhang, Guangyong Sui, Qijia Niu, Yimeng Ye, Weilong Ma, Guowu Liu, Huiying Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review |
title | Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review |
title_full | Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review |
title_fullStr | Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review |
title_full_unstemmed | Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review |
title_short | Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review |
title_sort | research progress of functional motifs based on growth factors in cartilage tissue engineering: a review |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941568/ https://www.ncbi.nlm.nih.gov/pubmed/36824354 http://dx.doi.org/10.3389/fbioe.2023.1127949 |
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